Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization. - Wikidata - wikimedia - TriplyDB

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

http://www.wikidata.org/entity/Q34345289

about

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells Cell biology and pathology of podocytes Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation History and progression of Fat cadherins in health and disease A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis Control of neuronal morphology by the atypical cadherin Fat3 The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells Loss of full length CtBP1 expression enhances the invasive potential of human melanoma.Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset.Cofilin-1 in the podocyte: a molecular switch for actin dynamics.Proteinuria: an enzymatic disease of the podocyte?Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products Sleeping giants: emerging roles for the fat cadherins in health and disease.FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.Anchoring junctions as drug targets: role in contraceptive development.Hippo signaling: growth control and beyond.Utero-vaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome) associated with deletions in known DiGeorge or DiGeorge-like loci.Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium Role of the podocyte in proteinuria.Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.Expanding the morphogenetic repertoire: perspectives from the Drosophila egg Round and round gets you somewhere: collective cell migration and planar polarity in elongating Drosophila egg chambers.Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes FAT1 mutations cause a glomerulotubular nephropathy Disparate Regulatory Mechanisms Control Fat3 and P75NTR Protein Transport through a Conserved Kif5-Interaction Domain FAT4 functions as a tumour suppressor in gastric cancer by modulating Wnt/β-catenin signalling.Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP.Clinical impact of research on the podocyte slit diaphragm.Function and cancer genomics of FAT family genes (review)Fat3 and Ena/VASP proteins influence the emergence of asymmetric cell morphology in the developing retina FAT1: a potential target for monoclonal antibody therapy in colon cancer.

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P2860

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

http://www.wikidata.org/entity/Q34345289

description

2004 nî lūn-bûn

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2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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type

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Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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prefLabel

Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

@ast

Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

@en

Protocadherin FAT1 binds Ena/V ...... ynamics and cell polarization.

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SJ.EMBOJ.7600380

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The EMBO Journal

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Protocadherin FAT1 binds Ena/V ...... dynamics and cell polarization

@en

P2093

Abdulsalam Soofi

http://www.w3.org/2001/XMLSchema#string

Lawrence B Holzman

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Marcus J Moeller

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Wilhelm Kriz

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Xiaodong Li

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly

Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes

Molecular cloning and characterization of Pals, proteins associated with mLin-7

Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.

Rho GTPases control polarity, protrusion, and adhesion during cell movement

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

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10.1038/SJ.EMBOJ.7600380

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19

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522787

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