In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase.
about
A mechanism for the synergistic antimalarial action of atovaquone and proguanilClinical relevance of genetic polymorphisms in the human CYP2C subfamilySummary of information on human CYP enzymes: human P450 metabolism data.Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.Role of drug metabolism in drug discovery and development.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolutionRelationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian populationSubstrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism.Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug.Inhibition and induction of human cytochrome P450 enzymes: current status.Preparation of the HIV-infected Traveler to the Tropics.Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe.In vivo and in vitro antimalarial activity of 4-nerolidylcatechol.Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent.Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.Importance of cytochromes in cyclization reactions: quantum chemical study on a model reaction of proguanil to cycloguanil.Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.Analyses of Biguanides and Related Compounds in Biological and Environmental Samples by HPLC
P2860
Q24550657-814184BB-AB30-4030-A587-03252395480FQ28362533-FD7A1D5C-2225-4633-8088-2145731F73A8Q32103802-7FDAFD44-523C-4950-800D-CE8E05498B7BQ33851108-6CDACE9A-C2E6-43A4-AE84-389CEA8DAB58Q34347052-09AC854F-BA03-4C70-BE8A-21173F8A2E9DQ34386829-98DF2870-8279-494D-8622-93F9EFB63A72Q35015993-8EB78FBD-CE84-4E8E-9839-10A0FEAA34F9Q35137054-59D21381-20E0-4413-BB4B-AD5345307F8AQ35802629-3EA24B2D-E5A8-4793-B446-3E99D4247A50Q35929431-04FA9812-BB5F-40DA-A127-60CAB280B50DQ36053568-9CA7269A-4AFA-4A7C-A62D-80BC36E675C4Q36718456-D5FB9198-40BF-42E5-931B-73B30883E5EFQ37212794-035875E3-C1E1-45C3-B050-E20A0D403E02Q39122084-5ED4B4A1-E2A2-487E-A01B-6FFCCD510708Q39222197-ABBC79FC-34B8-4CBC-A4E0-8056B966FB6EQ39403142-F02073A1-200B-4AAB-81F9-18AF51FCB895Q41119883-EBECD8CC-EBCB-4905-8091-A6ACB5E977CBQ41595607-C0BE1CD1-CB5E-4C42-9D0F-9AB543A0AE5CQ41931375-6D42D4E8-886F-4669-AA6C-ED722AABDFD2Q46842312-8F9C17E1-81ED-416C-8F0C-2B6E98A06AF3Q54003849-F011AAE9-E0E4-47C5-838A-1D03EED89190Q59150041-DF628390-C17F-49AE-A0DA-FB0B4D45161C
P2860
In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@ast
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@en
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@nl
type
label
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@ast
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@en
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@nl
prefLabel
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@ast
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@en
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@nl
P2093
P2860
P1476
In vitro proguanil activation ...... by S-mephenytoin hydroxylase.
@en
P2093
D J Birkett
F J Gonzalez
J O Miners
M E Veronese
T Andersson
P2860
P304
P356
10.1111/J.1365-2125.1994.TB05707.X
P407
P577
1994-05-01T00:00:00Z