Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells
about
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexIdentification of PP2A complexes and pathways involved in cell transformationTargeting protein serine/threonine phosphatases for drug developmentAdapting the Stress Response: Viral Subversion of the mTOR Signaling PathwayThe role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancerSimian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.The canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein.JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activityEffects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection.Activation of the PI3K/AKT pathway in Merkel cell carcinomaHuman cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth controlRestricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibitionCircumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent mannerViruses - seeking and destroying the tumor program.Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia.Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells.A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elementsThe TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway.Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.Measles virus-induced immunosuppression: from effectors to mechanisms.Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.Immortalization of swine umbilical vein endothelial cells (SUVECs) with the simian virus 40 large-T antigen.Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation.Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas.The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathwayIn vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model.
P2860
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P2860
Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Simian virus 40 small tumor an ...... owth of human epithelial cells
@ast
Simian virus 40 small tumor an ...... owth of human epithelial cells
@en
Simian virus 40 small tumor an ...... owth of human epithelial cells
@nl
type
label
Simian virus 40 small tumor an ...... owth of human epithelial cells
@ast
Simian virus 40 small tumor an ...... owth of human epithelial cells
@en
Simian virus 40 small tumor an ...... owth of human epithelial cells
@nl
prefLabel
Simian virus 40 small tumor an ...... owth of human epithelial cells
@ast
Simian virus 40 small tumor an ...... owth of human epithelial cells
@en
Simian virus 40 small tumor an ...... owth of human epithelial cells
@nl
P2093
P2860
P1433
P1476
Simian virus 40 small tumor an ...... owth of human epithelial cells
@en
P2093
Kathleen Rundell
Richard Schlegel
Tim Veldman
P2860
P304
10685-10691
P356
10.1128/JVI.76.21.10685-10691.2002
P407
P577
2002-11-01T00:00:00Z