PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
about
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent mannerPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12mTOR: from growth signal integration to cancer, diabetes and ageingCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTORAmino acids and mTORC1: from lysosomes to diseaseThe TORC2 component, Sin1, controls migration of anterior mesendoderm during zebrafish gastrulationmTOR kinase structure, mechanism and regulationRag proteins regulate amino-acid-induced mTORC1 signalling.Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life ExpectancyLa-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signalingComputational modeling and analysis of insulin induced eukaryotic translation initiationPRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathwaysIntestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsRegulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.Enhancing mTOR-targeted cancer therapy.Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia.mTOR signaling in lymphangioleiomyomatosisHigh-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathwaysThe phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.Mechanistic target of rapamycin complex 2 protects the heart from ischemic damageCryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation.PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts.Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eyeThe abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age.The evolution of the TOR pathway and its role in cancer.Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.Rheb and Rags come together at the lysosome to activate mTORC1.Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.
P2860
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P2860
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
PRAS40 is a target for mammali ...... ing downstream of this complex
@ast
PRAS40 is a target for mammali ...... ing downstream of this complex
@en
PRAS40 is a target for mammali ...... ing downstream of this complex
@en-gb
PRAS40 is a target for mammali ...... ing downstream of this complex
@nl
type
label
PRAS40 is a target for mammali ...... ing downstream of this complex
@ast
PRAS40 is a target for mammali ...... ing downstream of this complex
@en
PRAS40 is a target for mammali ...... ing downstream of this complex
@en-gb
PRAS40 is a target for mammali ...... ing downstream of this complex
@nl
prefLabel
PRAS40 is a target for mammali ...... ing downstream of this complex
@ast
PRAS40 is a target for mammali ...... ing downstream of this complex
@en
PRAS40 is a target for mammali ...... ing downstream of this complex
@en-gb
PRAS40 is a target for mammali ...... ing downstream of this complex
@nl
P2093
P2860
P3181
P356
P1476
PRAS40 is a target for mammali ...... ing downstream of this complex
@en
P2093
Bruno D Fonseca
Ewan M Smith
Vivian H-Y Lee
P2860
P304
P3181
P356
10.1074/JBC.M704406200
P407
P577
2007-08-24T00:00:00Z