Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
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ATRX dysfunction induces replication defects in primary mouse cellsNew players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperoneTelomere regulation in pluripotent stem cellsAlternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progressionHistone H3 mutations--a special role for H3.3 in tumorigenesis?Modern brain tumor imagingRNase P protein subunit Rpp29 represses histone H3.3 nucleosome depositionAn Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies.The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeTelomere elongation chooses TERRA ALTernativesLoss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer CellsATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichmentGenetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma CellsHistone H3.3 maintains genome integrity during mammalian developmentThe somatic genomic landscape of glioblastomaMolecular Markers in Low-Grade Glioma-Toward Tumor ReclassificationDecreased expression of the chromatin remodeler ATRX associates with melanoma progressionEpidemiologic and molecular prognostic review of glioblastomaPML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cellsDisease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site.ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function.Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.Research progress of neuroblastoma related gene variations.Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.Histone variants: emerging players in cancer biology.Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas.Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairImpact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.Telomere maintenance mechanisms in cancer: clinical implicationsRNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeresLoss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.The genome of the chicken DT40 bursal lymphoma cell line.Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathwaysIntegrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.
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P2860
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@ast
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@en
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@nl
type
label
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@ast
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@en
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@nl
prefLabel
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@ast
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@en
Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@nl
P2093
P2860
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Loss of ATRX, genome instabili ...... gthening of telomeres pathway.
@en
P2093
ALT Starr Cancer Consortium
Alan K Meeker
Barbara A Weir
Charlie Hatton
Courtney A Lovejoy
Elena Ivanova
Joanne Bruno
John H J Petrini
Laura Macconaill
Maria Jasin
P2860
P304
P356
10.1371/JOURNAL.PGEN.1002772
P4510
P577
2012-07-19T00:00:00Z