Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.
about
The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosomeA homeodomain protein binds to gamma-globin gene regulatory sequencesEarly myeloid cell-specific expression of the human cathepsin G gene in transgenic miceIntron requirement for expression of the human purine nucleoside phosphorylase geneA composite transposon 3' to the cow fetal globin gene binds a sequence specific factorAn erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genesInitiation of DNA replication at the human beta-globin 3' enhancer.Current and future alternative therapies for beta-thalassemia majorHeart and bone tumors in transgenic miceNovel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombinationExpression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses.Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice.Histone- and protamine-DNA association: conservation of different patterns within the beta-globin domain in human sperm.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionAdjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene clusterThe beta-globin dominant control region: hypersensitive site 2Multiple enhancer-like sequences in the HLA-B7 geneIdentification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.Molecular analysis of the human beta-globin locus activation region.Cardiac and neurological abnormalities in v-fps transgenic mice.The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive siteMyosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice.Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Analyses of linked beta-globin genes suggest that nondeletion forms of hereditary persistence of fetal hemoglobin are bona fide switching mutants.Recombinant human hemoglobins designed for gene therapy of sickle cell diseaseA 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expressionTwo tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase geneIdentification of a conserved sequence in the non-coding regions of many human genes.Structure and function of the enhancer 3' to the human A gamma globin geneThe beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic miceA common protein binds to two silencers 5' to the human beta-globin gene.The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.
P2860
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P2860
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.
description
1987 nî lūn-bûn
@nan
1987 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@ast
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@en
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@nl
type
label
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@ast
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@en
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@nl
prefLabel
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@ast
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@en
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@nl
P2093
P2860
P356
P1476
Two 3' sequences direct adult ...... obin genes in transgenic mice.
@en
P2093
R D Palmiter
R E Hammer
R L Brinster
R R Behringer
T M Townes
P2860
P304
P356
10.1073/PNAS.84.20.7056
P407
P577
1987-10-01T00:00:00Z