Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia - Wikidata - wikimedia - TriplyDB

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

http://www.wikidata.org/entity/Q34352771

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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders Mechanisms of granulin deficiency: lessons from cellular and animal models Mouse models of frontotemporal dementia Potential mechanisms of progranulin-deficient FTLD Progranulin: at the interface of neurodegenerative and metabolic diseases A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1.A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish.Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.Progranulin: a promising therapeutic target for rheumatoid arthritis.Core features of frontotemporal dementia recapitulated in progranulin knockout mice.Progranulin: a growth factor, a novel TNFR ligand and a drug target Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.The central nervous system is a target of acute graft versus host disease in mice.Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia.Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice.Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.Cellular effects of progranulin in health and disease.Structure, function, and mechanism of progranulin; the brain and beyond.

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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

http://www.wikidata.org/entity/Q34352771

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2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010年の論文

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Yao Ma

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P2860

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Cytokines sing the blues: inflammation and the pathogenesis of depression

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development.

Progranulin is expressed within motor neurons and promotes neuronal cell survival

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

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