EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding
about
The three transfer RNAs occupying the A, P and E sites on the ribosome are involved in viral programmed -1 ribosomal frameshiftElongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-TuMovement in ribosome translocation.Kinetics of initiating polypeptide elongation in an IRES-dependent systemStructural insights into ribosome translocationtRNA–mRNA mimicry drives translation initiation from a viral IRESStructures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation.Structural basis for hygromycin B inhibition of protein biosynthesisThe process of mRNA-tRNA translocationAminoglycoside activity observed on single pre-translocation ribosome complexes.Interrupted catalysis: the EF4 (LepA) effect on back-translocation.tRNA dynamics on the ribosome during translation.The ribosome as an entropy trapRibosomes in a stacked array: elucidation of the step in translation elongation at which they are stalled during S-adenosyl-L-methionine-induced translation arrest of CGS1 mRNA.Spontaneous formation of the unlocked state of the ribosome is a multistep process.A fast dynamic mode of the EF-G-bound ribosome.Direct measurement of the mechanical work during translocation by the ribosome.Navigating the ribosome's metastable energy landscapeA new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET.Structure and dynamics of a processive Brownian motor: the translating ribosomeA molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-siteColicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes.The hybrid state of tRNA binding is an authentic translation elongation intermediateThe conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesisInsights into the molecular determinants of EF-G catalyzed translocation.Identification of two distinct hybrid state intermediates on the ribosomeIrreversible chemical steps control intersubunit dynamics during translation.Structure of ratcheted ribosomes with tRNAs in hybrid statesSingle-molecule observations of ribosome functionAlmost lost in translation. Cryo-EM of a dynamic macromolecular complex: the ribosome.Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.Structural Insights into tRNA Dynamics on the Ribosome.Multiple effects of S13 in modulating the strength of intersubunit interactions in the ribosome during translation.A 16S rRNA-tRNA product containing a nucleotide phototrimer and specific for tRNA in the P/E hybrid state in the Escherichia coli ribosome.Spontaneous intersubunit rotation in single ribosomes.Kinetically competent intermediates in the translocation step of protein synthesis.Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosomeGTP hydrolysis by EF-G synchronizes tRNA movement on small and large ribosomal subunits.Ribosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo.Changes in the conformation of 5S rRNA cause alterations in principal functions of the ribosomal nanomachine.
P2860
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P2860
EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@ast
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@en
EF-G-independent reactivity of ...... mycin supports an intermediate
@nl
type
label
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@ast
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@en
EF-G-independent reactivity of ...... mycin supports an intermediate
@nl
prefLabel
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@ast
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@en
EF-G-independent reactivity of ...... mycin supports an intermediate
@nl
P2093
P2860
P356
P1433
P1476
EF-G-independent reactivity of ...... (hybrid) state of tRNA binding
@en
P2093
Daniel R Southworth
Divya Sharma
Rachel Green
P2860
P304
P356
10.1261/RNA.5148704
P407
P577
2004-01-01T00:00:00Z