Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome - Wikidata - wikimedia - TriplyDB

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome

http://www.wikidata.org/entity/Q34365749

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Developmental Dynamics of Rett Syndrome Rett Syndrome: Crossing the Threshold to Clinical Translation Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders MECP2 disorders: from the clinic to mice and back MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction Rett Syndrome: Reaching for Clinical Trials Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development SHANK proteins: roles at the synapse and in autism spectrum disorder.Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype.Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice.Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.Intravascular AAV9 Administration for Delivering RNA Silencing Constructs to the CNS and Periphery.Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.What you seize is what you get: do we yet understand epilepsy in rett syndrome?Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice.A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome.Reduced phenotypic severity following adeno-associated virus-mediated Fmr1 gene delivery in fragile X mice.Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits Astrocyte-specific regulation of hMeCP2 expression in Drosophila.Biomechanical properties of bone in a mouse model of Rett syndrome.Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates.Gene therapy for the nervous system: challenges and new strategies.Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.Clinical applications involving CNS gene transfer.Methods for gene transfer to the central nervous system.Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System.MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice.Epigenetics, autism spectrum, and neurodevelopmental disorders.

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Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome

http://www.wikidata.org/entity/Q34365749

description

2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

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JNEUROSCI.1854-13.2013

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Journal of Neuroscience

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Systemic delivery of MeCP2 res ...... mouse models of Rett syndrome

@en

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Brian K Kaspar

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Daniel T Lioy

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Gail Mandel

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John M Bissonnette

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Kevin D Foust

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Matthew J Murtha

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Saurabh K Garg

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P2860

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

MeCP2, a key contributor to neurological disease, activates and represses transcription

The story of Rett syndrome: from clinic to neurobiology

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Reversal of neurological defects in a mouse model of Rett syndrome

Wild-type microglia arrest pathology in a mouse model of Rett syndrome.

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.

MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy

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13612-13620

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scholarly article

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10.1523/JNEUROSCI.1854-13.2013

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34

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33

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Adrian Peter Bird

Hélène Cheval

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2013-08-01T00:00:00Z

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256072798

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23966684

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3755711

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