Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. - Wikidata - wikimedia - TriplyDB

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

http://www.wikidata.org/entity/Q30524829

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MECP2 disorders: from the clinic to mice and back Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective.Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice Preclinical research in Rett syndrome: setting the foundation for translational success.Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome.Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndrome Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome.Characterization of the MeCP2R168X knockin mouse model for Rett syndrome.Biomechanical properties of bone in a mouse model of Rett syndrome.Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING.Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice.Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome.Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Understanding the rhythm of breathing: so near, yet so far.MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2 Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation.Breathing challenges in Rett syndrome: lessons learned from humans and animal models.Reduced neuronal size and mTOR pathway activity in the Mecp2 A140V Rett syndrome mouse model Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology Recent Progress in Rett Syndrome and MeCP2 Dysfunction: Assessment of Potential Treatment Options Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation.Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice.Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain.Synaptic plasticity and signaling in Rett syndrome.Rett syndrome: a complex disorder with simple roots.The utility of rodent models of autism spectrum disorders Prospects for the development of epigenetic drugs for CNS conditions.Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.Autism spectrum disorder: neuropathology and animal models.Childhood disorders of the synapse: challenges and opportunities.CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model.MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

http://www.wikidata.org/entity/Q30524829

description

2012 nî lūn-bûn

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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2012 թվականի ապրիլին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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type

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

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Cara Merusi

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Dina De Sousa

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Emma Brockett

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Gernot Riedel

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Jacky Guy

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Jim Selfridge

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Leanne McKay

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Lianne Robinson

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Rosemary C Spike

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Stuart R Cobb

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P2860

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice

Rett syndrome: revised diagnostic criteria and nomenclature

Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

Can we relate MeCP2 deficiency to the structural and chemical abnormalities in the Rett brain?

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

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2699-2710

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10.1093/BRAIN/AWS096

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Pt 9

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135

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Adrian Peter Bird

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2012-04-23T00:00:00Z

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224823805

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