An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
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The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolyticsGABA A receptors: subtypes provide diversity of function and pharmacologyProbing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative reviewAMPAKINE enhancement of social interaction in the BTBR mouse model of autismGABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism.Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected].Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory.Prepulse inhibition and genetic mouse models of schizophrenia.GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.Molecular targets for treating cognitive dysfunction in schizophrenia.Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brainAutomated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer.Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse ModelEffects of an α5GABAA inverse agonist on MK-801-induced learning deficits in an incremental repeated acquisition task.Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease.Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors.GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline.The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonistsPWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning.Synthesis, molecular structure and characterization of allylic derivatives of 6-amino-3-methyl-1,2,4-triazolo[3,4-f][1,2,4]-triazin-8(7H)-one.Synaptic alpha 5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex.An Investigation of the Differential Effects of Ursane Triterpenoids from Centella asiatica, and Their Semisynthetic Analogues, on GABAA Receptors.Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice.Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAA alpha5-subtype inverse agonist.
P2860
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P2860
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
An orally bioavailable, functi ...... ognition enhancing properties.
@ast
An orally bioavailable, functi ...... ognition enhancing properties.
@en
An orally bioavailable, functi ...... ognition enhancing properties.
@nl
type
label
An orally bioavailable, functi ...... ognition enhancing properties.
@ast
An orally bioavailable, functi ...... ognition enhancing properties.
@en
An orally bioavailable, functi ...... ognition enhancing properties.
@nl
prefLabel
An orally bioavailable, functi ...... ognition enhancing properties.
@ast
An orally bioavailable, functi ...... ognition enhancing properties.
@en
An orally bioavailable, functi ...... ognition enhancing properties.
@nl
P2093
P356
P1476
An orally bioavailable, functi ...... cognition enhancing properties
@en
P2093
Angus M Macleod
Desmond O'connor
George Marshall
Gerard R Dawson
Mark S Chambers
Neil Collinson
Pushpindar Ferris
Robert W Carling
Sarah C Hobbs
Susan M Cook
P304
P356
10.1021/JM040863T
P407
P50
P577
2004-11-01T00:00:00Z