RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.
about
Predictive models for customizing chemotherapy in advanced non-small cell lung cancer (NSCLC)Genome stability pathways in head and neck cancersAn RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.BRCA1 pathway function in basal-like breast cancer cells.Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repairEctopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1In vitro and in vivo radiosensitization induced by hydroxyapatite nanoparticles.Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.DNA damage emergency: cellular garbage disposal to the rescue?Mechanisms of resistance to therapies targeting BRCA-mutant cancers.Customized chemotherapy in metastatic non-small cell lung cancer (NSCLC)HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies.The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.DNA Strand Breaks in Mitotic Germ Cells of Caenorhabditis elegans Evaluated by Comet Assay.RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors.ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.The development of PARP as a successful target for cancer therapy.Differential expression of homologous recombination DNA repair genes in the early and advanced stages of myelodysplastic syndrome.Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies.PARP inhibitors: the journey from research hypothesis to clinical approval.
P2860
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P2860
RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@ast
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@en
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@nl
type
label
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@ast
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@en
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@nl
prefLabel
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@ast
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@en
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@nl
P1433
P1476
RNF8 regulates assembly of RAD ...... he absence of BRCA1 and 53BP1.
@en
P2093
Rikako Miyamoto Yonamine
P304
P356
10.1158/0008-5472.CAN-12-1057
P407
P577
2012-08-03T00:00:00Z