RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1 - Wikidata - wikimedia - TriplyDB

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1

http://www.wikidata.org/entity/Q36418906

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Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.53BP1 promotes microhomology-mediated end-joining in G1-phase cells.DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8 Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.DNA damage sensing by the ATM and ATR kinases.Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.53BP1 fosters fidelity of homology-directed DNA repair.Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.Regulation of Single-Strand Annealing and its Role in Genome Maintenance.Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.PRPF8 is important for BRCA1-mediated homologous recombination.USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

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RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1

http://www.wikidata.org/entity/Q36418906

description

2012 nî lūn-bûn

@nan

2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@ast

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@en

type

label

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@ast

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@en

prefLabel

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@ast

RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@en

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JBC.M112.410951

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Journal of Biological Chemistry

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RING finger nuclear factor RNF ...... er susceptibility factor BRCA1

@en

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Amanda Gunn

http://www.w3.org/2001/XMLSchema#string

André Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Anita Cheng

http://www.w3.org/2001/XMLSchema#string

Corentin Laulier

http://www.w3.org/2001/XMLSchema#string

Davide F Robbiani

http://www.w3.org/2001/XMLSchema#string

Jeremy M Stark

http://www.w3.org/2001/XMLSchema#string

Meilen C Muñoz

http://www.w3.org/2001/XMLSchema#string

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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

Human CtIP promotes DNA end resection

Integrated genomic analyses of ovarian carcinoma

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40618-40628

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scholarly article

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10.1074/JBC.M112.410951

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48

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287

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2012-10-10T00:00:00Z

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23055523

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3504775

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