Identification of AF-6 and canoe as putative targets for Ras. - Wikidata - wikimedia - TriplyDB

Identification of AF-6 and canoe as putative targets for Ras.

Identification of AF-6 and canoe as putative targets for Ras.

http://www.wikidata.org/entity/Q34371134

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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6 MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1 Ras-induced cellular events (review)Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6 Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 RalGDS functions in Ras- and cAMP-mediated growth stimulation Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis Association rate constants of ras-effector interactions are evolutionarily conserved Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction Stimulation of gene induction and cell growth by the Ras effector Rlf Ras oncogenes: split personalities A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.Genomic organization, tissue expression, and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia.The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family.Growth factor signaling pathways in vascular development.TC21 and Ras share indistinguishable transforming and differentiating activities.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.AF6 negatively regulates Rap1-induced cell adhesion.Effects of herpes simplex virus on structure and function of nectin-1/HveC.Death pathways triggered by activated Ras in cancer cells Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.

P2860

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P2860

Identification of AF-6 and canoe as putative targets for Ras.

http://www.wikidata.org/entity/Q34371134

description

1996 nî lūn-bûn

@nan

1996 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1996 թվականի հունվարին հրատարակված գիտական հոդված

@hy

1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

Identification of AF-6 and canoe as putative targets for Ras.

@ast

Identification of AF-6 and canoe as putative targets for Ras.

@en

Identification of AF-6 and canoe as putative targets for Ras.

@nl

type

label

Identification of AF-6 and canoe as putative targets for Ras.

@ast

Identification of AF-6 and canoe as putative targets for Ras.

@en

Identification of AF-6 and canoe as putative targets for Ras.

@nl

prefLabel

Identification of AF-6 and canoe as putative targets for Ras.

@ast

Identification of AF-6 and canoe as putative targets for Ras.

@en

Identification of AF-6 and canoe as putative targets for Ras.

@nl

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P1433

Journal of Biological Chemistry

P1476

Identification of AF-6 and canoe as putative targets for Ras.

@en

P2093

A Iwamatsu

http://www.w3.org/2001/XMLSchema#string

D Yamamoto

http://www.w3.org/2001/XMLSchema#string

E Canaani

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K Kaibuchi

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M Kuriyama

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M Nakafuku

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N Harada

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R Prasad

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S Kuroda

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T Yamamoto

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P2860

Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Basic local alignment search tool

Mammalian Ras interacts directly with the serine/threonine kinase Raf

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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2

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271

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Carlo Maria Croce

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