Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
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S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2Glycogen synthase kinase 3: more than a namesakeApolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistanceRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cellsGSK-3: Functional Insights from Cell Biology and Animal Models.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.GSK-3beta and control of glucose metabolism and insulin action in human skeletal muscleOverstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity.IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects.Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistanceBeta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker ratsTargeting GSK-3 family members in the heart: a very sharp double-edged sword.What Are the bona fide GSK3 Substrates?Polycystic ovary syndrome in the pediatric populationInsulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation.Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism.Frontal Bone Insufficiency in Gsk3β Mutant Mice.Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty ratsPreliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndromeTurning signals on and off: GLUT4 traffic in the insulin-signaling highway.Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by LipidInsulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase ActivationAmino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscleShilianhua extract inhibits GSK-3beta and promotes glucose metabolism.Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic SyndromePhosphorylation of IRS proteins, insulin action, and insulin resistance.Expression and function of the insulin receptor substrate proteins in cancerAdipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3.Testosterone supplementation improves glucose homeostasis despite increasing hepatic insulin resistance in male mouse model of type 2 diabetes mellitus.Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cellsWhy do anti-inflammatory therapies fail to improve insulin sensitivity?Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue.In vitro streptozotocin model for modeling Alzheimer-like changes: effect on amyloid precursor protein secretases and glycogen synthase kinase-3.Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.
P2860
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P2860
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@ast
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@en
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@nl
type
label
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@ast
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@en
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@nl
prefLabel
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@ast
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@en
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@nl
P356
P1476
Serine 332 phosphorylation of ...... attenuates insulin signaling.
@en
P2093
Ziva Liberman
P304
P356
10.1074/JBC.M410610200
P407
P577
2004-11-30T00:00:00Z