Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
about
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonistThe metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridineThe glutamatergic system as a target for neuropathic pain relief(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addictionReduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Arthritis and pain. Future targets to control osteoarthritis painMetabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways.Novel neuroinflammatory targets in the chronically injured spinal cordEffect of chronic pain on fentanyl self-administration in mice.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.Therapeutic potential of metabotropic glutamate receptor modulators.Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOREffects of metabotropic glutamate receptor ligands on male sexual behavior in rats.Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord.Is there hope for chronic pain and headache?Central sensitization: a generator of pain hypersensitivity by central neural plasticity.Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain.A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.mGlu5 negative allosteric modulators: a patent review (2010-2012).Therapeutic potential of targeting glutamate receptors in Parkinson's disease.Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK Profile.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors.Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyChanges in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.Evaluation of the effects of a metabotropic glutamate receptor 5-antagonist on electrically induced pain and central sensitization in healthy human volunteers.Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice.Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery.
P2860
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P2860
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@ast
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@en
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@nl
type
label
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@ast
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@en
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@nl
prefLabel
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@ast
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@en
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@nl
P2093
P1476
Assessing the role of metabotr ...... ltiple nociceptive modalities.
@en
P2093
Carol T Wismer
Carrie L Wade
Chang Z Zhu
Donna M Gauvin
James J Lynch
Joseph P Mikusa
Michael W Decker
Prisca Honore
Sonya G Wilson
P304
P356
10.1016/J.EJPHAR.2004.11.005
P407
P577
2004-12-01T00:00:00Z