LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.
about
The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specializationComputer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeletonLim kinase, a bi-functional effector in injury-induced structural plasticity of synapsesKeratinocyte migration in the developing eyelid requires LIMK2Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion.LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis.Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption.Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft modelBis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsThe serum protein profile of early parity which induces protection against breast cancer.Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.Harnessing allostery: a novel approach to drug discovery.Pathogenic microbes manipulate cofilin activity to subvert actin cytoskeleton.Roles of LIM kinases in central nervous system function and dysfunction.Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cellsMitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration.Allosteric modulators of MEK1: drug design and discovery.LIM kinases: cofilin and beyond.Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway.Investigational serine/threonine kinase inhibitors against prostate cancer metastases.LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2.Molecular pathways: targeting the kinase effectors of RHO-family GTPases.Effect of LIM kinase 1 overexpression on behaviour of endometriosis-derived stromal cells.Targeting LIM kinase in cancer and neurofibromatosis.Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth.Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions.Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors
P2860
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P2860
LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
LIM kinases are attractive tar ...... few small molecule regulators.
@ast
LIM kinases are attractive tar ...... few small molecule regulators.
@en
LIM kinases are attractive tar ...... few small molecule regulators.
@nl
type
label
LIM kinases are attractive tar ...... few small molecule regulators.
@ast
LIM kinases are attractive tar ...... few small molecule regulators.
@en
LIM kinases are attractive tar ...... few small molecule regulators.
@nl
prefLabel
LIM kinases are attractive tar ...... few small molecule regulators.
@ast
LIM kinases are attractive tar ...... few small molecule regulators.
@en
LIM kinases are attractive tar ...... few small molecule regulators.
@nl
P356
P1476
LIM kinases are attractive tar ...... few small molecule regulators.
@en
P2093
Fabrizio Manetti
P304
P356
10.1002/MED.20230
P577
2011-01-16T00:00:00Z