Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
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The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceDesign of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONSCrystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITYSupramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOTFully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein CrystallographyAn Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic designChiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainStructural basis for the lower affinity of the insulin-like growth factors for the insulin receptor.The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.ADAPTIVE FINITE ELEMENT MODELING TECHNIQUES FOR THE POISSON-BOLTZMANN EQUATION.Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir.Insulin: a model system for nanomedicine?Precise mapping of an IGF-I-binding site on the IGF-1R.Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.
P2860
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P2860
Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
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2004 nî lūn-bûn
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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@ast
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@en
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@nl
type
label
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@ast
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@en
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@nl
prefLabel
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@ast
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@en
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@nl
P2093
P356
P1433
P1476
Enhancing the activity of insu ...... cross-linking of A8 analogues.
@en
P2093
Michael A Weiss
Panayotis G Katsoyannis
Satoe H Nakagawa
Shi-Quan Hu
Ying-Chi Chu
P304
16119-16133
P356
10.1021/BI048223F
P407
P577
2004-12-01T00:00:00Z