Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor.
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesCloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting proteinInsulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsThe proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationStructural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteinsHuman GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domainsThe cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerizationKinase activation through dimerization by human SH2-BMouse disabled (mDab1): a Src binding protein implicated in neuronal developmentSignal-dependent membrane targeting by pleckstrin homology (PH) domainsTyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migrationSequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainAssociation of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic functionStructural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domainStructure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesionsThe Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseDistinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializationsMembrane Binding and Modulation of the PDZ Domain of PICK1Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1Multiple modes of peptide recognition by the PTB domain of the cell fate determinant NumbStructural basis of SNT PTB domain interactions with distinct neurotrophic receptorsStructural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.Crystal structures of the Dab homology domains of mouse disabled 1 and 2An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin bindingCrystal structure of the human Fe65-PTB1 domainStructural Basis for CD44 Recognition by ERM ProteinsStructural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunitsStructure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificityRe-engineering the target specificity of the insulin receptor by modification of a PTB domain binding siteSignaling via Shc family adapter proteinsMolecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrinPhosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domainRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cellsInteraction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activationCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesInsulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolasesSuppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
P2860
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P2860
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor.
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@ast
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@en
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@nl
type
label
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@ast
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@en
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@nl
prefLabel
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@ast
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@en
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@nl
P2093
P1433
P1476
Structure of the IRS-1 PTB dom ...... egion of the insulin receptor.
@en
P2093
P304
P356
10.1016/S0092-8674(00)81236-2
P407
P577
1996-05-01T00:00:00Z