Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity.
about
A cDNA clone expressed in natural killer and T cells that likely encodes a secreted proteinHuman perforin employs different avenues to damage membranesZanvil Alexander Cohn 1926-1993Cloning CTL-Specific Genes (And Now for Something Completely Differential)Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlookControl of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells.Cell adhesion and the immune system: a case study using earthworms.Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytesPerforin rapidly induces plasma membrane phospholipid flip-flopStepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes.Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis.Effects of MACPF/CDC proteins on lipid membranes.Perforin-mediated target-cell death and immune homeostasis.Perforin deficiency and susceptibility to cancer.Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cellsJapanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain.Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agentsPerforin activity at membranes leads to invaginations and vesicle formation.Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replicIn vivo expression of perforin by natural killer cells during a viral infection. Studies on uveitis produced by herpes simplex virus type I.Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity.A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes.Resistance of cytolytic lymphocytes to perforin-mediated killing. Lack of correlation with complement-associated homologous species restriction.Antibacterial activity of human natural killer cellsResistance of cytolytic lymphocytes to perforin-mediated killing. Induction of resistance correlates with increase in cytotoxicity.Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granulesGranzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation.Extracellular ATP as a trigger for apoptosis or programmed cell death.The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.Extracellular release of lymphocyte cytolytic pore-forming protein (perforin) after ionophore stimulation.Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.Protein arcs may form stable pores in lipid membranes.Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.
P2860
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P2860
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity.
description
1986 nî lūn-bûn
@nan
1986 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի մարտին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Purification and characterizat ...... with natural killer activity.
@ast
Purification and characterizat ...... with natural killer activity.
@en
Purification and characterizat ...... with natural killer activity.
@nl
type
label
Purification and characterizat ...... with natural killer activity.
@ast
Purification and characterizat ...... with natural killer activity.
@en
Purification and characterizat ...... with natural killer activity.
@nl
prefLabel
Purification and characterizat ...... with natural killer activity.
@ast
Purification and characterizat ...... with natural killer activity.
@en
Purification and characterizat ...... with natural killer activity.
@nl
P2093
P1433
P1476
Purification and characterizat ...... with natural killer activity.
@en
P2093
P304
P356
10.1016/0092-8674(86)90007-3
P407
P577
1986-03-01T00:00:00Z