A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.
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Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activationCould Vitamin D Analogues Be Used to Target Leukemia Stem Cells?Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?The myeloma stem cell concept, revisited: from phenomenology to operational terms(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB.The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138(-) CD34(-) tumor stem-like cells in multiple myeloma-bearing mice.Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma.Genetic background affects susceptibility to tumoral stem cell reprogramming.Function of oncogenes in cancer development: a changing paradigm.Genomic instability in multiple myeloma: mechanisms and therapeutic implications.Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy.Pre-malignant lymphoid cells arise from hematopoietic stem/progenitor cells in chronic lymphocytic leukemia.Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms.SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.Lineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T-cell blast crisis.The cellular architecture of multiple myeloma.Back to the beginning: The initiation of cancer.MafA is critical for maintenance of the mature beta cell phenotype in mice.The Making of Leukemia.MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma.Lmo2 expression defines tumor cell identity during T-cell leukemogenesisA multiple myeloma classification system that associates normal B-cell subset phenotypes with prognosis
P2860
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P2860
A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A novel molecular mechanism in ...... to haematopoietic progenitors.
@ast
A novel molecular mechanism in ...... to haematopoietic progenitors.
@en
A novel molecular mechanism in ...... to haematopoietic progenitors.
@nl
type
label
A novel molecular mechanism in ...... to haematopoietic progenitors.
@ast
A novel molecular mechanism in ...... to haematopoietic progenitors.
@en
A novel molecular mechanism in ...... to haematopoietic progenitors.
@nl
prefLabel
A novel molecular mechanism in ...... to haematopoietic progenitors.
@ast
A novel molecular mechanism in ...... to haematopoietic progenitors.
@en
A novel molecular mechanism in ...... to haematopoietic progenitors.
@nl
P2093
P2860
P50
P356
P1433
P1476
A novel molecular mechanism in ...... to haematopoietic progenitors.
@en
P2093
Alberto Orfao
Diego Alonso-López
Esther Alonso-Escudero
Fernando Abollo-Jiménez
Francisco Javier García Criado
Inés González-Herrero
Isabel Romero-Camarero
Isidro Sánchez-García
Izidore S Lossos
Ma Carmen Fernández Criado
P2860
P304
P356
10.1038/EMBOJ.2012.227
P407
P50
P577
2012-08-17T00:00:00Z