Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design
about
Design of LNA probes that improve mismatch discriminationLocked nucleic acid (LNA) mediated improvements in siRNA stability and functionalityAdvanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the BrainA regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplexA lncRNA Perspective into (Re)Building the HeartmRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotidesInhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth.Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primatesAllele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication.Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.Antisense growth inhibition of methicillin-resistant Staphylococcus aureus by locked nucleic acid conjugated with cell-penetrating peptide as a novel FtsZ inhibitor.Detection of pathogen-specific antibodies by loop-mediated isothermal amplification.LNA-based oligonucleotide electrotransfer for miRNA inhibition.Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP).DEADSouth protein localizes to germ plasm and is required for the development of primordial germ cells in Xenopus laevis.Sub-cellular temporal and spatial distribution of electrotransferred LNA/DNA oligomerDelivery of RNAi-Based Oligonucleotides by ElectropermeabilizationIntracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs).Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.2'-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro.Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.Optimization of an AMBER force field for the artificial nucleic acid, LNA, and benchmarking with NMR of L(CAAU).Using non-coding small RNAs to develop therapies for Huntington's disease.Effect of LNA- and OMeN-modified oligonucleotide probes on the stability and discrimination of mismatched base pairs of duplexes.Selection, optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site.Strong positional preference in the interaction of LNA oligonucleotides with DNA polymerase and proofreading exonuclease activities: implications for genotyping assays.Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA.Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics.Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling.Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication.Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probesLNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells.High-Technology Therapy Using Biomolecules or Synthetic Compounds for HIV InhibitionOn the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide
P2860
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P2860
Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Antisense inhibition of gene e ...... et sequence and chimera design
@ast
Antisense inhibition of gene e ...... et sequence and chimera design
@en
Antisense inhibition of gene e ...... et sequence and chimera design
@nl
type
label
Antisense inhibition of gene e ...... et sequence and chimera design
@ast
Antisense inhibition of gene e ...... et sequence and chimera design
@en
Antisense inhibition of gene e ...... et sequence and chimera design
@nl
prefLabel
Antisense inhibition of gene e ...... et sequence and chimera design
@ast
Antisense inhibition of gene e ...... et sequence and chimera design
@en
Antisense inhibition of gene e ...... et sequence and chimera design
@nl
P2093
P2860
P356
P1476
Antisense inhibition of gene e ...... et sequence and chimera design
@en
P2093
David R Corey
Dwaine A Braasch
Yinghui Liu
P2860
P304
P356
10.1093/NAR/GKF651
P407
P577
2002-12-01T00:00:00Z