Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
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Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLDMetabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and HepatokinesWhole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcomePhenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activityIdentification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression.GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.Expression and clinical significance of fibroblast growth factor 1 in gastric adenocarcinoma.A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient dietβ-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetesEffective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver diseaseFibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation.Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 ExpressionFibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice.Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance.The Effect of Sitagliptin on Lipid Metabolism of Fatty Liver Mice and Related Mechanisms.Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese mice.A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease.Fibroblast growth factor 21 induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region.Targeting endoplasmic reticulum stress in liver disease.Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver.Endoplasmic reticulum proteostasis in hepatic steatosis.FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process.Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism.Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress.Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver diseaseGlucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.Diverse Changes of Circulating Fibroblast Growth Factor 21 Levels in Hepatitis B Virus-Related Diseases.Clinical and genetic characterisation of infantile liver failure syndrome type 1, due to recessive mutations in LARS.Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice.Endoplasmic reticulum stress in the pathogenesis of fibrotic disease.Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice.The eIF2-alpha kinase HRI: a potential target beyond the red blood cell.FGF21-induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway.Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.FGF21 Is an Exocrine Pancreas Secretagogue.Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver.
P2860
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P2860
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@ast
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@en
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@nl
type
label
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@ast
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@en
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@nl
prefLabel
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@ast
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@en
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@nl
P2093
P2860
P356
P1476
Fibroblast growth factor 21 is ...... ress-induced hepatic steatosis
@en
P2093
Hua-ting Li
Jing-qi Liu
Qi-chen Fang
Shan Jiang
Wei-ping Jia
Yi-ping Deng
P2860
P304
29751-29765
P356
10.1074/JBC.M114.565960
P407
P577
2014-08-28T00:00:00Z