Fragment based drug design: from experimental to computational approaches.
about
Computational approaches in target identification and drug discoveryFocusing on shared subpockets - new developments in fragment-based drug discoveryAssessment and challenges of ligand docking into comparative models of G-protein coupled receptorsTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryUnique identifiers for small molecules enable rigorous labeling of their atoms.Avidity-controlled delivery of angiogenic peptides from injectable molecular-recognition hydrogelsEvolutions in fragment-based drug design: the deconstruction-reconstruction approachFragment-based strategy for structural optimization in combination with 3D-QSAR.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead DiscoveryOn the origins of three-dimensionality in drug-like molecules.Switches of hydrogen bonds during ligand-protein association processes determine binding kinetics.Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategyNew insights into the kinetic target-guided synthesis of protein ligands.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide.Considerations of Protein Subpockets in Fragment-Based Drug Design.Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4.Marine Diterpenes: Molecular Modeling of Thrombin Inhibitors with Potential Biotechnological Application as an Antithrombotic.Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology.Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors.Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds.#Nitrosocarbonyls 1: antiviral activity of N-(4-hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the influenza A virus H1N1.The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils
P2860
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P2860
Fragment based drug design: from experimental to computational approaches.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Fragment based drug design: from experimental to computational approaches.
@ast
Fragment based drug design: from experimental to computational approaches.
@en
Fragment based drug design: from experimental to computational approaches.
@nl
type
label
Fragment based drug design: from experimental to computational approaches.
@ast
Fragment based drug design: from experimental to computational approaches.
@en
Fragment based drug design: from experimental to computational approaches.
@nl
prefLabel
Fragment based drug design: from experimental to computational approaches.
@ast
Fragment based drug design: from experimental to computational approaches.
@en
Fragment based drug design: from experimental to computational approaches.
@nl
P1476
Fragment based drug design: from experimental to computational approaches
@en
P2093
P304
P356
10.2174/092986712803530467
P50
P577
2012-01-01T00:00:00Z