Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. - Wikidata - wikimedia - TriplyDB

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

http://www.wikidata.org/entity/Q34398151

about

LRP-1: a checkpoint for the extracellular matrix proteolysis Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase Involvement of heparanase in atherosclerosis and other vessel wall pathologies Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration.PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model Insights into the key roles of proteoglycans in breast cancer biology and translational medicine Fibroblast growth factors as tissue repair and regeneration therapeutics.Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.Expression of heparanase in soft tissue sarcomas of adults.Conformational changes of 1-4-glucopyranosyl residues of a sulfated C-C linked hexasaccharide Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent Heparanase cooperates with Ras to drive breast and skin tumorigenesis Heparanase enhances myeloma progression via CXCL10 downregulation.Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.Synthesis of a pseudo-disaccharide library and its application to the characterisation of the heparanase catalytic site In vitro and ex vivo evaluation of a multi-epitope heparinase vaccine for various malignancies.DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma.Heparan sulfate differences in rheumatoid arthritis versus healthy sera Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine Prostaglandins in cancer cell adhesion, migration, and invasion Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy Overexpression of heparanase multiple antigenic peptide 2 is associated with poor prognosis in gastric cancer: Potential for therapy Significance of heparanase in cancer and inflammation.Deciphering mode of action of heparanase using structurally defined oligosaccharides.Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.Bioengineered heparins and heparan sulfates.

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P2860

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

http://www.wikidata.org/entity/Q34398151

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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type

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Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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Proteoglycans in health and di ...... or progression and metastasis.

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Ilana Dowek

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Israel Vlodavsky

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Neta Ilan

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Ralph D Sanderson

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Uri Barash

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Victoria Cohen-Kaplan

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P2860

Human heparanase. Purification, characterization, cloning, and expression

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

Heparanase induces endothelial cell migration via protein kinase B/Akt activation

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

Tumor self-seeding by circulating cancer cells

Syndecans in tumor cell adhesion and signaling

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

Cloning and functional expression of a human heparanase gene

Identification of active-site residues of the pro-metastatic endoglycosidase heparanase

Soluble syndecan-1 promotes growth of myeloma tumors in vivo

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3890-3903

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