Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
about
Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequenceHeparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityHeparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VIISulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancerErythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitroHeparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myelomaNephroprotective effect of heparanase in experimental nephrotic syndromeMatrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisCloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activityNewly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesCharacterization of a novel intracellular heparanase that has a FERM domain.Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.Heparan sulfate, heparin, and heparinase activity detection on polyacrylamide gel electrophoresis using the fluorochrome tris(2,2'-bipyridine) ruthenium (II).Loss of Endocan tumorigenic properties after alternative splicing of exon 2.Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cellsSmall RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cellsGenetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donorsThe β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and MenUnraveling the specificity of heparanase utilizing synthetic substrates.Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice.Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasisThe breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis.Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasisTumorigenic and adhesive properties of heparanase.Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cellsHeparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1)Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.Heparanase and coagulation-new insights.Cell surface heparan sulfate and its roles in assisting viral infections.Role of endothelial heparanase in delayed-type hypersensitivity.Antagonising angiogenesis in rheumatoid arthritisExpression and significance of heparanase and nm23-H1 in hepatocellular carcinomaA liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase.Mammalian heparanase: what is the message?
P2860
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P2860
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@ast
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@en
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@nl
type
label
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@ast
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@en
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@nl
prefLabel
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@ast
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@en
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@nl
P2093
P3181
P356
P1433
P1476
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
@en
P2093
B J Hamdorf
C R Parish
M D Hulett
M J Harris
P2888
P3181
P356
10.1038/10525
P407
P577
1999-07-01T00:00:00Z