PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.
about
Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury.Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory ResponsePerispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidenceAcute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytesIncreased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.The contribution of astrocytes and microglia to traumatic brain injuryInhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury.Defective phosphoinositide metabolism in autism.The PI3Kδ inhibitor idelalisib suppresses liver and lung cellular respiration."Neurological complications of new chemotherapy agents".The PI3K Pathway in Human Disease.Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.Effects of ischemic postconditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia.
P2860
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P2860
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.
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PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@ast
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@en
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@nl
type
label
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@ast
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@en
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@nl
prefLabel
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@ast
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@en
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@nl
P2093
P2860
P50
P356
P1476
PI3Kδ inhibition reduces TNF s ...... a mouse cerebral stroke model.
@en
P2093
Bart Vanhaesebroeck
Brad R S Broughton
Christopher G Sobey
Mathias Gelderblom
Pei Ching Low
Tam H Nguyen
Thiruma V Arumugam
Tim Magnus
Vinod K Narayana
P2860
P2888
P356
10.1038/NCOMMS4450
P407
P50
P577
2014-03-14T00:00:00Z
P5875
P6179
1051176274