Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
about
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loopJTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stressHuman Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical CancerHigh-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillationsQuantitative imaging of mammalian transcriptional dynamics: from single cells to whole embryosToxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathwaysChemical memory reactions induced bursting dynamics in gene expressionA design principle of group-level decision making in cell populationsTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2The effects of interleukin-2 on immune response regulation.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 inductionSignal-dependent dynamics of transcription factor translocation controls gene expression.Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expressionDivision of labour between Myc and G1 cyclins in cell cycle commitment and pace controlChlamydia infection depends on a functional MDM2-p53 axisDNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cellsProtein degradation rate is the dominant mechanism accounting for the differences in protein abundance of basal p53 in a human breast and colorectal cancer cell lineDynamics of posttranslational modifications of p53.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Modeling the basal dynamics of p53 system.A synthetic-natural hybrid oscillator in human cellsp53 dynamics control cell fateUltradian oscillations and pulses: coordinating cellular responses and cell fate decisionsNew insights into the link between DNA damage and apoptosis.Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damageMaking sense of ubiquitin ligases that regulate p53.Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.Mechanisms that enhance sustainability of p53 pulsesRegulation of DNA damage responses and cell cycle progression by hMOB2.DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate controlEDD inhibits ATM-mediated phosphorylation of p53.Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signalsTP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity
P2860
Q24310683-79D5DEF6-43BC-4C5D-8C0A-DD63BE7AA205Q24338903-1E5C6AD8-5A6B-4AFA-8367-77CC9D581C37Q26799484-4A72055E-4D7E-4032-8576-D8560F3D70A1Q27318882-F4A6866D-C128-4DB0-98E6-DCC5E1668C41Q28074628-2B808FD9-4E12-4687-AB85-BC7DF10BDB98Q28478650-D260CB99-475D-41A8-A557-95BA8069177CQ28485200-832D185E-3CB0-4ACA-9542-EBA7CFA93148Q28534350-3524B229-6D83-446C-94A0-B80983D9BC50Q28552677-D861FBFE-DE11-4E7C-BD50-CC9CE2287EF1Q28818349-A9CDD430-2131-44C5-9C4D-8C8C2AF9F0CCQ30252875-2BDC6418-4763-4685-BF56-006C88C2489BQ30505355-30BAF6AB-49B9-4303-A8B7-1EDC8EB09E2BQ30572790-F4C0C7DA-1433-448A-B11F-135ACD935A9EQ30579303-B6E6D430-F15D-41DC-B8FC-18904EE83601Q30587011-737BD219-9160-403B-8217-CF1E7740638AQ30601745-EB2CA0C6-8876-44A5-9389-BA6175879AB1Q30842780-E0A1F94A-CD9F-40B7-942D-31D8C7D8CE84Q31090728-2951AA18-C6F5-4F36-BEBF-07EE4BDFFE23Q33572789-6F730003-8565-46BB-9D83-171AA639D151Q33657982-CB19A12E-64BD-4045-ADA9-F6B7BF71B9ECQ33679142-641CE36F-D684-47C6-B4B2-1D9FFE8834F4Q33720383-DB38D0FB-9D49-42A1-8E7A-AC34EEAA7676Q33764435-8CA82729-733B-411A-81E7-32A8C0BBF92AQ33791305-15FDCEFB-1840-48BE-96A5-F2C3150EC320Q34082945-8C31CDD2-A6B5-4468-BEA6-678BB2D3C1A1Q34165397-226C6CB0-8B31-424F-A305-7176722E077AQ34173945-C1B02718-F7D6-4990-931B-4B853167D1D9Q34341432-879CD643-F00A-430B-B237-063A97E303DEQ34425503-1B798381-4FD5-4385-AB81-0FC8A5494402Q34483943-1F3BC657-6F91-49D9-8F7D-91F6F31C7493Q34503497-8C0991DC-ADE7-4302-9E88-BB25DA842108Q34592125-2187E64F-84C1-46C6-A7F7-86CC58F3F2E0Q34729763-56B82075-AFE4-4AAD-A2BC-B64B7F18370AQ34766227-9325B8FC-92B0-40ED-9E95-9F352385C506Q34771336-56C65AAA-C6AA-4479-A52C-545B248663E1Q34783261-E42703DD-8064-4158-AEF0-EF1993892B94Q34869507-9B84B273-A984-4963-AFDE-34D9E5262F0EQ34986145-B576B1A0-77AD-42C8-9111-6F80B89177FAQ35000817-9B72FB65-4E02-4075-9723-A9E61CAC2578Q35042948-823D5817-453D-4188-AEA7-5A5203135F08
P2860
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@ast
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@en
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@nl
type
label
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@ast
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@en
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@nl
prefLabel
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@ast
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@en
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
@nl
P2860
P1433
P1476
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
@en
P2093
Galit Lahav
Giorgio Gaglia
P2860
P304
P356
10.1016/J.CELL.2010.05.031
P407
P577
2010-07-01T00:00:00Z