Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Item
http://www.wikidata.org/entity/Q34416260
The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer.Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKGA novel thermoregulatory role for PDE10A in mouse and human adipocytesThe Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.Validation of PDE5 as a Chemoprevention Target.Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium.Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005.Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia
P2860

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Item
http://www.wikidata.org/entity/Q34416260
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
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2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
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2014年論文
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2014年论文
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name
Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
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Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
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Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
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Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
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Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
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Phosphodiesterase 10A: a novel ...... t TCF transcriptional activity
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P6179
P698
P932