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Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

http://www.wikidata.org/entity/Q28575617

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Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications Phosphodiesterases in neurodegenerative disorders Structural insight into substrate specificity of phosphodiesterase 10 Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity HPRT-deficiency dysregulates cAMP-PKA signaling and phosphodiesterase 10A expression: mechanistic insight and potential target for Lesch-Nyhan Disease?TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate Effects of a novel phosphodiesterase 10A inhibitor in non-human primates: A therapeutic approach for schizophrenia with improved side effect profile Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition Phosphodiesterase 10A inhibitor MP-10 effects in primates: comparison with risperidone and mechanistic implications Approaches and tools for modeling signaling pathways and calcium dynamics in neurons Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease Modulation of mGlu2 Receptors, but Not PDE10A Inhibition Normalizes Pharmacologically-Induced Deviance in Auditory Evoked Potentials and Oscillations in Conscious Rats.Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference.Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity The distribution of phosphodiesterase 2A in the rat brain.Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder.A novel thermoregulatory role for PDE10A in mouse and human adipocytes Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET.The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons.Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine] in rats: pot Radiosynthesis and biological evaluation of the new PDE10A radioligand [18 F]AQ28A.Potential drug targets and treatment of schizophrenia.FACS purification of immunolabeled cell types from adult rat brain.Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity.Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.Modeling spatial aspects of intracellular dopamine signaling.

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P2860

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

http://www.wikidata.org/entity/Q28575617

description

2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մայիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2006

@ast

im Mai 2006 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2006/05/12)

@sk

vědecký článek publikovaný v roce 2006

@cs

wetenschappelijk artikel (gepubliceerd op 2006/05/12)

@nl

наукова стаття, опублікована в травні 2006

@uk

مقالة علمية (نشرت في 12-5-2006)

@ar

name

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@ast

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@en

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

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type

label

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@ast

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@en

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@nl

prefLabel

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@ast

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

@en

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

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J.NEUROSCIENCE.2005.12.042

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Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

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A. B. Jakowski

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C. A. Strick

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D. G. Morton

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D. T. Stephenson

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F. S. Menniti

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R. D. Williams

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R. J. Kleiman

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W. D. Eldred

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W. O. Adamowicz

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Z. Xie

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P2860

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

PDZ domains and the organization of supramolecular complexes

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation

Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A

Immunohistochemical localization of PDE10A in the rat brain

Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

PDZ domain proteins of synapses

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