Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.
about
Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genesGlutamate receptors in neuroinflammatory demyelinating diseaseBiochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptorsParaneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratomaTaking the time to study competitive antagonismAn MCASE approach to the search of a cure for Parkinson's Disease.Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding coreStructural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate ReceptorsFormation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly.Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuriaCharacterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonistsAllosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brainDesensitization of NMDA receptor channels is modulated by glutamate agonists.The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunitExcitatory glycine receptors containing the NR3 family of NMDA receptor subunitsInfluence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptorsMolecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment.Enhancing exposure-based therapy from a translational research perspective.Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.Novel CNS glutamate receptor subunit genes of Drosophila melanogaster.Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors.Recent excitement in the ionotropic glutamate receptor field.Coping with dehydration: sympathetic activation and regulation of glutamatergic transmission in the hypothalamic PVN.Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus.Ligands for ionotropic glutamate receptorsSynaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation.Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation.Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes.Staggering of subunits in NMDAR channels.The use of ketamine in complex regional pain syndrome: possible mechanisms.Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors.NMDA receptor and neonatal hypoxic brain injury.GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.Expression and plasticity of glutamate receptors in the supraoptic nucleus of the hypothalamus.Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites.E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate.Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.
P2860
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P2860
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Molecular determinants of agon ...... ding site on the NR2B subunit.
@ast
Molecular determinants of agon ...... ding site on the NR2B subunit.
@en
Molecular determinants of agon ...... ding site on the NR2B subunit.
@nl
type
label
Molecular determinants of agon ...... ding site on the NR2B subunit.
@ast
Molecular determinants of agon ...... ding site on the NR2B subunit.
@en
Molecular determinants of agon ...... ding site on the NR2B subunit.
@nl
prefLabel
Molecular determinants of agon ...... ding site on the NR2B subunit.
@ast
Molecular determinants of agon ...... ding site on the NR2B subunit.
@en
Molecular determinants of agon ...... ding site on the NR2B subunit.
@nl
P2093
P1433
P1476
Molecular determinants of agon ...... ding site on the NR2B subunit.
@en
P2093
P304
P356
10.1016/S0896-6273(00)81249-0
P407
P577
1997-03-01T00:00:00Z