Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. - Wikidata - wikimedia - TriplyDB

Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.

Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.

http://www.wikidata.org/entity/Q34431070

about

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans Animal models of polyglutamine diseases and therapeutic approaches Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases Lessons learned from the transgenic Huntington's disease rats Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.Medium- and high-throughput screening of neurotoxicants using C. elegans.Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans.Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms A cellular perspective on conformational disease: the role of genetic background and proteostasis networks.Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling Dying for a cause: invertebrate genetics takes on human neurodegeneration.Inhibitors of metabolism rescue cell death in Huntington's disease models.Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans Protein homeostasis in models of aging and age-related conformational disease.Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein.What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research.Polyglutamine misfolding in yeast: toxic and protective aggregation.Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Animal models of neurodegenerative diseases.Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.Distinct mechanisms of mutant huntingtin toxicity in different yeast strains.A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast.Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases.In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model.Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state.Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases.Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity.

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Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.

http://www.wikidata.org/entity/Q34431070

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Proceedings of the National Academy of Sciences of the United States of America

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Glutamine/proline-rich PQE-1 p ...... n polyglutamine neurotoxicity.

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Cindy Voisine

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Daphne C King

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Emily A Bates

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Peter W Faber

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P2860

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

WormBase: network access to the genome and biology of Caenorhabditis elegans

A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

Genome sequence of the nematode C. elegans: a platform for investigating biology

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast.

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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26

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99

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Caenorhabditis elegans

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