The cellular thermal shift assay for evaluating drug target interactions in cells. - Wikidata - wikimedia - TriplyDB

The cellular thermal shift assay for evaluating drug target interactions in cells.

The cellular thermal shift assay for evaluating drug target interactions in cells.

http://www.wikidata.org/entity/Q34432745

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Targeting Oncogenic Mutant p53 for Cancer Therapy CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells Identification of CETP as a molecular target for estrogen positive breast cancer cell death by cholesterol depleting agents Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD.Time, space, and disorder in the expanding proteome universe.Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.Target engagement and drug residence time can be observed in living cells with BRET.Insights into neuroepigenetics through human histone deacetylase PET imaging.Validation and development of MTH1 inhibitors for treatment of cancer.Mitigating risk in academic preclinical drug discovery.Global analysis of protein folding thermodynamics for disease state characterization Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.Non-stoichiometric inhibition in integrated lead finding - a literature review.Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60.Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells.A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosis Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor.Developing Spindlin1 small-molecule inhibitors by using protein microarrays.New strategy for drug discovery by large-scale association analysis of molecular networks of different species.Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types.Antagonizing STAT5B dimerization with an osmium complex.The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer.CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.Solution NMR Spectroscopy in Target-Based Drug Discovery.Inhibitors of protein methyltransferases as chemical tools.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells.Inhibiting epidermal growth factor receptor signalling potentiates mesenchymal-epithelial transition of breast cancer stem cells and their responsiveness to anticancer drugs.

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P2860

The cellular thermal shift assay for evaluating drug target interactions in cells.

http://www.wikidata.org/entity/Q34432745

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

The cellular thermal shift assay for evaluating drug target interactions in cells.

@ast

The cellular thermal shift assay for evaluating drug target interactions in cells.

@en

The cellular thermal shift assay for evaluating drug target interactions in cells.

@nl

type

label

The cellular thermal shift assay for evaluating drug target interactions in cells.

@ast

The cellular thermal shift assay for evaluating drug target interactions in cells.

@en

The cellular thermal shift assay for evaluating drug target interactions in cells.

@nl

prefLabel

The cellular thermal shift assay for evaluating drug target interactions in cells.

@ast

The cellular thermal shift assay for evaluating drug target interactions in cells.

@en

The cellular thermal shift assay for evaluating drug target interactions in cells.

@nl

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Nature Protocols

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The cellular thermal shift assay for evaluating drug target interactions in cells.

@en

P2093

Daniel Martinez Molina

http://www.w3.org/2001/XMLSchema#string

Helena Almqvist

http://www.w3.org/2001/XMLSchema#string

Marina Ignatushchenko

http://www.w3.org/2001/XMLSchema#string

Pär Nordlund

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P2860

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control

Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Systematic identification of genomic markers of drug sensitivity in cancer cells

Thermofluor-based high-throughput stability optimization of proteins for structural studies

High-density miniaturized thermal shift assays as a general strategy for drug discovery

P2888

P304

2100-2122

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scholarly article

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10.1038/NPROT.2014.138

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9

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9

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Thomas Lundbäck

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2014-08-07T00:00:00Z

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264641715

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1008993025

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25101824

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