Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells

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Apoptotic and genomic effects of corilagin on SKOV3 ovarian cancer cell line.CDDO and Its Role in Chronic Diseases.HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue.

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Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells

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2015 nî lūn-bûn

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Hsp90 Is a Novel Target Molecu ...... ration of Ovarian Cancer Cells

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Hsp90 Is a Novel Target Molecu ...... ration of Ovarian Cancer Cells

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Hsp90 Is a Novel Target Molecu ...... ration of Ovarian Cancer Cells

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Cai-Xia Tang

http://www.w3.org/2001/XMLSchema#string

Chun-Min Ma

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Dong-Jun Qin

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Feng-Hou Gao

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Han-Zhang Xu

http://www.w3.org/2001/XMLSchema#string

Hu Lei

http://www.w3.org/2001/XMLSchema#string

Li Yang

http://www.w3.org/2001/XMLSchema#string

Wei Wei

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Ying-Li Wu

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Ying-Ying Wang

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Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Cancer statistics, 2014

Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.

CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.

A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.

The cellular thermal shift assay for evaluating drug target interactions in cells.

Hsp90: a chaperone for protein folding and gene regulation.

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scholarly article

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10.1371/JOURNAL.PONE.0132337

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English

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2015-07-02T00:00:00Z

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280030484

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ovarian cancer

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Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells

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P2860

P2860

Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells

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