HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.
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Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activitySubverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cellsProtective effects of alanyl-glutamine supplementation against nelfinavir-induced epithelial impairment in IEC-6 cells and in mouse intestinal mucosa.Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and preventionRecent advances in drug repositioning for the discovery of new anticancer drugsAcute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series.The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitroSignal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.Sexual Dysfunctions of HIV-Positive Men: Associated Factors, Pathophysiology Issues, and Clinical Management.HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress.Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer.Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway.Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential.HIV protease inhibitors impact on apoptosis.Repositioning HIV protease inhibitors as cancer therapeuticsThe impact of nelfinavir exposure on cancer development among a large cohort of HIV-infected patientsHuman immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.Phase I study of nelfinavir in liposarcoma.Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy.Targeting endoplasmic reticulum signaling pathways in cancer.Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers.HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts.The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivoLong-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene.Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling.Clinical presentation and outcomes of prostate cancer in an urban cohort of predominantly African American, human immunodeficiency virus-infected patients.Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer.Nelfinavir induces radiation sensitization in pituitary adenoma cells.Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.Beyond androgen deprivation: ancillary integrative strategies for targeting the androgen receptor addiction of prostate cancer.The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo.The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies.
P2860
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P2860
HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@ast
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@en
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@nl
type
label
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@ast
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@en
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@nl
prefLabel
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@ast
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@en
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@nl
P2093
P2860
P1433
P1476
HIV-1 protease inhibitor induc ...... eptor STAT3 and AKT signaling.
@en
P2093
H Phillip Koeffler
Hirokuni Taguchi
Seisho Takeuchi
Takayuki Ikezoe
Tamotsu Takeuchi
Yoshihiro Adachi
Yuji Ohtsuki
P2860
P304
P356
10.1111/J.1349-7006.2005.00063.X
P577
2005-07-01T00:00:00Z