Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.

Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.

Item
http://www.wikidata.org/entity/Q34445935
Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.Morphine decreases enteric neuron excitability via inhibition of sodium channels.Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum.Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestine.Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivityBivalent ligands targeting chemokine receptor dimerization: molecular design and functional studies.Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effectsBinding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mStructure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists.Novel cyclic biphalin analogue with improved antinociceptive properties.Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
P2860

Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.

Item
http://www.wikidata.org/entity/Q34445935
description
1989 nî lūn-bûn
@nan
1989 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@ast
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@en
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@nl
type
label
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@ast
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@en
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@nl
prefLabel
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@ast
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@en
Synthesis and biological evalu ...... mu opioid receptor antagonist.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Synthesis and biological evalu ...... mu opioid receptor antagonist
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921