Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
about
Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats.Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivityDesign, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists.Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behaviorDesign, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand.Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists.Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics forOpioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.
P2860
Q33815047-DD33FF1E-782C-41EF-B495-7B3B984FDE19Q35027648-305BD32F-C5B6-4588-AD4A-BF457559B2A0Q35216655-E0689284-9ED2-482D-8A39-825A7D24F826Q35236118-39C39743-6E0F-4A59-97E3-9652C20E2F13Q36090988-D67EDFBB-5E83-4089-BCFD-B35ECF50C08CQ36296493-6141EB2C-A115-4241-A7C9-71DEE671A7E9Q36480105-1BCD6D88-9CA6-441F-B774-21497588255BQ36839084-ACA18AA6-7441-41E7-B991-0A8AC546004BQ37417284-20BF6505-2F18-4D11-9944-F2660CCBD79BQ37444418-50233DC1-DE13-40C9-AF64-3D4941C7D2E0Q38373652-C1942D6D-9826-47C4-B61F-1DD134B373DEQ42633385-001517F6-6F8D-4875-B0F0-9A2AB46DBC76Q43117967-01B349E3-1131-4D7B-9B59-1A320B244503Q47147106-1D264D56-E395-4DD4-A6A4-22AB8E76911A
P2860
Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@ast
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@en
type
label
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@ast
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@en
prefLabel
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@ast
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@en
P2093
P2860
P356
P1476
Characterization of 6α- and 6β ...... eceptor selective antagonists.
@en
P2093
Dana E Selley
David L Stevens
Hengjun He
Krista L Scoggins
Pallabi Mitra
Patrick Kozak
Phillip M Gerk
William L Dewey
P2860
P304
P356
10.1021/CN2000348
P577
2011-05-06T00:00:00Z