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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

http://www.wikidata.org/entity/Q34449486

about

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo The Rationale for Insulin Therapy in Alzheimer's Disease Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418 Toxin-Induced Experimental Models of Learning and Memory Impairment The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta The ups and downs of Wnt signaling in prevalent neurological disorders FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited GSK3beta in ethanol neurotoxicity The role of GSK3beta in the development of the central nervous system Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils Evidence for a role of glycogen synthase kinase-3 beta in rodent spermatogenesis Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain A novel calcium-binding protein is associated with tau proteins in tauopathy NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations C3G regulates the size of the cerebral cortex neural precursor population GSK3β Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills.Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.Post-ischemic estradiol treatment reduced glial response and triggers distinct cortical and hippocampal signaling in a rat model of cerebral ischemia.GSK-3: Functional Insights from Cell Biology and Animal Models.Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.Glycogen synthase kinase-3 in the etiology and treatment of mood disorders.Is glycogen synthase kinase-3 a central modulator in mood regulation?Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.Estradiol activates beta-catenin dependent transcription in neurons.

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P2860

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

http://www.wikidata.org/entity/Q34449486

description

2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հունվարին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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type

label

Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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prefLabel

Decreased nuclear beta-catenin ...... ta conditional transgenic mice

@ast

Decreased nuclear beta-catenin ...... ta conditional transgenic mice

@en

Decreased nuclear beta-catenin ...... ta conditional transgenic mice

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The EMBO Journal

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Decreased nuclear beta-catenin ...... ta conditional transgenic mice

@en

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Avila J

http://www.w3.org/2001/XMLSchema#string

Gómez-Ramos P

http://www.w3.org/2001/XMLSchema#string

Hen R

http://www.w3.org/2001/XMLSchema#string

Morán MA

http://www.w3.org/2001/XMLSchema#string

P2860

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Amyloid plaque core protein in Alzheimer disease and Down syndrome

A molecular mechanism for the effect of lithium on development

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

Direct association of presenilin-1 with beta-catenin

Alzheimer's disease: paired helical filaments and cytomembranes

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27-39

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10.1093/EMBOJ/20.1.27

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1-2

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