CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.
about
The function of APC/CCdh1 in cell cycle and beyondDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionRegulation of the transcription factor FOXM1c by Cyclin E/CDK2Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phasePhosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destructionProtein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinMechanisms to control rereplication and implications for cancer.Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationThe Non-Canonical Role of Aurora-A in DNA ReplicationNetwork calisthenics: control of E2F dynamics in cell cycle entryRegulation of Unperturbed DNA Replication by UbiquitylationTo live or let die - complexity within the E2F1 pathwayFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisSpatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cellsStructure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylationModulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.Spatiotemporal regulation of the anaphase-promoting complex in mitosisCDC6: from DNA replication to cell cycle checkpoints and oncogenesisMammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phaseFra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcriptionCiz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitroAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Cdc45 limits replicon usage from a low density of preRCs in mammalian cellsThe APC/C inhibitor, Emi1, is essential for prevention of rereplicationCyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancerViral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.Cdk2 is required for p53-independent G2/M checkpoint control.Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationInteraction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication.APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.New roles for cyclin E in megakaryocytic polyploidization.A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.Control of DNA replication by cyclin-dependent kinases in developmentControl of centrin stability by Aurora A.Tension and robustness in multitasking cellular networks.
P2860
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P2860
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@ast
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@en
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@nl
type
label
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@ast
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@en
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@nl
prefLabel
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@ast
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@en
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@nl
P1433
P1476
CDKs promote DNA replication o ...... m APC/C-dependent proteolysis.
@en
P2093
Niels Mailand
P304
P356
10.1016/J.CELL.2005.08.013
P407
P577
2005-09-01T00:00:00Z