about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeIdentification and characterization of human MUS81-MMS4 structure-specific endonucleasePlk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentationPML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyRestoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiationImmunoglobulin class switch recombination is impaired in Atm-deficient miceDNA and the chromosome - varied targets for chemotherapyFrequency of CHEK2 mutations in a population based, case-control study of breast cancer in young womenFission yeast Rad26 responds to DNA damage independently of Rad3Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110)NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damagePhosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domainThe CHR site: definition and genome-wide identification of a cell cycle transcriptional elementThe response to and repair of RAG-mediated DNA double-strand breaksBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageThe CHEK2 gene and inherited breast cancer susceptibilityEDD mediates DNA damage-induced activation of CHK2Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseCheckpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancerChk2 suppresses the oncogenic potential of DNA replication-associated DNA damageXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsCell cycle-dependent localization of CHK2 at centrosomes during mitosis.The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum.Rad9 modulates the P21WAF1 pathway by direct association with p53.ATM and Chk2 kinase target the p53 cofactor StrapKaryopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.Evolutionary analysis of the highly dynamic CHEK2 duplicon in anthropoidsNovel design strategy for checkpoint kinase 2 inhibitors using pharmacophore modeling, combinatorial fusion, and virtual screening.Single-nucleotide polymorphisms in the p53 signaling pathway.Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer.The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibilityrasiRNAs, DNA damage, and embryonic axis specification.Controlling the Mdm2-Mdmx-p53 Circuit.Mechanism targeted discovery of antitumor marine natural products.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
CHK2 kinase--a busy messenger.
@ast
CHK2 kinase--a busy messenger.
@en
CHK2 kinase--a busy messenger.
@nl
type
label
CHK2 kinase--a busy messenger.
@ast
CHK2 kinase--a busy messenger.
@en
CHK2 kinase--a busy messenger.
@nl
prefLabel
CHK2 kinase--a busy messenger.
@ast
CHK2 kinase--a busy messenger.
@en
CHK2 kinase--a busy messenger.
@nl
P356
P1476
CHK2 kinase--a busy messenger
@en
P2093
P2888
P304
P356
10.1038/35103059
P50
P577
2001-12-01T00:00:00Z
P5875
P6179
1005636144