Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance - Wikidata - wikimedia - TriplyDB

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

http://www.wikidata.org/entity/Q34458906

about

ISG15 deficiency and increased viral resistance in humans but not mice Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.USP18 lack in microglia causes destructive interferonopathy of the mouse brain.Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling.Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species.Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation.Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins.STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.Structural basis of the specificity of USP18 toward ISG15.Multiple functions of USP18.ISGylation - a key to lock the cell gates for preventing the spread of threats.USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.ISG15 governs mitochondrial function in macrophages following vaccinia virus infection.Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.Distinct Effects of Type I and III Interferons on Enteric Viruses.Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease.Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules.USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1

P2860

Q27317417-35E27EFD-82D7-4C46-949C-163409DC9E10 Q28084005-725EF390-904C-4AD5-A771-594264850C67 Q30829791-E99CEA38-907F-4D28-81D3-96AC6FF4FDE9 Q33792940-13556248-743A-4FF1-AE27-F8AB8CA4627D Q35762623-FE5D1E89-5183-4F7A-A017-E233C0D9A5AA Q35837348-51C8C7E1-D324-4439-99C5-BF10D6308555 Q36030376-610AF8AD-9820-4525-8D83-5C4120E07435 Q36076825-58FB1293-8EA3-4A53-A5E0-2052D3EE85CA Q36081845-1C3F821D-21DD-46D1-AEAC-F7514C18B13C Q36694038-3C9C552C-8A7B-453C-B068-0474F854526B Q37073335-4441FDF7-2E52-4B82-ACF4-F82030DB9B6C Q37086155-1A2E2A4B-62C3-497C-AD3F-10920220DCB6 Q37261013-F8C14D9D-B50F-4197-A8C6-9B4BDCA78149 Q38717767-A10EBF01-644B-4FA0-841C-14E75B6DAACF Q38976984-B3FE45A8-56BD-494C-8D77-C7B26BA58145 Q38997388-B1C4A845-EF9C-4277-BDBD-ED28026C9119 Q40079195-567E5587-D642-46BE-94EC-466D79021968 Q40471967-AD5A4906-6B5A-446A-A341-9D8E4781E6CE Q40691827-290D0A48-040A-469F-A8D3-85B5D4F09DC2 Q43294926-11CB3346-69FF-4A4B-8358-81C6F4C0D1A4 Q45948743-AF9194F6-87D5-4583-A86E-5744F78E3031 Q47549718-F61795EA-D8F0-41F8-8644-40F27A4DA67A Q47550996-156FF46A-4BEA-4876-8201-042218694B01 Q47841496-C954B05E-6E8B-4CCA-9D01-F655EDC17E97 Q49990366-2C167AE8-D165-4ABF-818A-148C6E1053BD Q50355495-95D91FCD-F3D2-49B1-957D-42C02D404ED6 Q57469903-66260C04-4FE9-48FE-993D-4CAA69173B0F

P2860

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

http://www.wikidata.org/entity/Q34458906

description

2015 nî lūn-bûn

@nan

2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Selective inactivation of USP1 ...... njugation and viral resistance

@ast

Selective inactivation of USP1 ...... njugation and viral resistance

@en

Selective inactivation of USP1 ...... njugation and viral resistance

@nl

type

label

Selective inactivation of USP1 ...... njugation and viral resistance

@ast

Selective inactivation of USP1 ...... njugation and viral resistance

@en

Selective inactivation of USP1 ...... njugation and viral resistance

@nl

prefLabel

Selective inactivation of USP1 ...... njugation and viral resistance

@ast

Selective inactivation of USP1 ...... njugation and viral resistance

@en

Selective inactivation of USP1 ...... njugation and viral resistance

@nl

P1433

Q34458906-48EFD526-6409-4A09-8EC6-C151BEB644A1

P1476

Q34458906-143CB75F-E6BD-4D05-99A7-3584E7562893

P2093

Q34458906-0BD0086E-60FF-459A-89AE-DB9FC3773E59

Q34458906-1ECC0A5C-9E2C-4C72-8B01-63EABFCF3B25

Q34458906-6DB9AD6C-24F9-4FA6-BD7C-64034C11DC36

Q34458906-AABC229B-5898-4978-A0DC-4E9CF74D91E2

Q34458906-C685E3A2-8FBA-4B28-BF63-A4C252E300A3

Q34458906-CCE5AD57-79A9-4AE9-928A-707B6E530661

Q34458906-DC903475-A284-422C-91F6-90BC952BAA8D

Q34458906-E32EF33D-162F-42A5-B3D7-86DD78183EF0

Q34458906-F54E7444-9F34-4122-B65E-FD31839F4620

P2860

Q34458906-0F6BD84F-3635-4089-BC58-5FA4E93BC4B5

Q34458906-1BFCE649-DF96-4298-B811-E6DFBFF47996

Q34458906-1D78D83E-249D-4BEB-ADF1-D80A301A6A8A

Q34458906-2525BA65-F046-423C-BDC0-4A755640E321

Q34458906-28B301C9-8D62-43C4-B4B8-8EABB0EEF934

Q34458906-33AD8447-54E7-4CDE-A63B-12BB06E6363B

Q34458906-34B5C1FC-1340-4DC6-8754-9FB9AFECA3FD

Q34458906-34FC2954-10A3-4FF5-9A25-9656BC1D53AD

Q34458906-434466B0-4DB7-444E-8C77-312E49C65361

Q34458906-4BD8E939-0ACC-48A7-B8F7-1F952F9B9D51

P304

Q34458906-4AAD7A94-ACC6-4299-B155-5C7064672D9B

P31

Q34458906-89C1D84F-F024-469D-9787-062366D78DBA

P356

Q34458906-67CCAA6A-CC87-47AD-B7C3-C9BC5F410E7A

P407

Q34458906-57394601-3D2D-4BEE-BEF1-C1278BF123C8

P433

Q34458906-607C3C94-B3AF-4782-927E-EFA69DA82391

P478

Q34458906-CA98E521-61DF-427F-907F-F56A3DF6DB31

P50

Q34458906-B07DB666-FA80-4410-90EB-1D57EF61757F

Q34458906-DAAD104D-6C6C-4048-9C7D-FA69D7BF918E

Q34458906-E15855C3-6C85-4D22-B0BD-A55A60E8FBDF

Q34458906-F957E02C-67C7-4197-97C5-3AAFE4A6ED28

P577

Q34458906-44C5AFA4-3F13-414D-97F7-712CA3AD4FD7

P5875

Q34458906-B04EA073-F153-43C7-B7EB-4E392CAB1CBC

P698

Q34458906-23D3D85F-7B62-47B7-A659-1835B285BEDD

P932

Q34458906-D1A0C949-F311-48FF-83D4-57A11B4581A2

P356

PNAS.1412881112

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Selective inactivation of USP1 ...... njugation and viral resistance

@en

P2093

Anja Basters

http://www.w3.org/2001/XMLSchema#string

Annika Hausmann

http://www.w3.org/2001/XMLSchema#string

David J Morales

http://www.w3.org/2001/XMLSchema#string

Deborah J Lenschow

http://www.w3.org/2001/XMLSchema#string

Klaus-Peter Knobeloch

http://www.w3.org/2001/XMLSchema#string

Marco Prinz

http://www.w3.org/2001/XMLSchema#string

Ronald Naumann

http://www.w3.org/2001/XMLSchema#string

Ronny Hannß

http://www.w3.org/2001/XMLSchema#string

Susana Guerra

http://www.w3.org/2001/XMLSchema#string

P2860

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

Protein ISGylation modulates the JAK-STAT signaling pathway

Interferon-inducible antiviral effectors

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

P304

1577-1582

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1412881112

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

112

http://www.w3.org/2001/XMLSchema#string

P50

Olaf Utermöhlen

Tobias Goldmann

P577

2015-01-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

271202834

http://www.w3.org/2001/XMLSchema#string

P698

25605921

http://www.w3.org/2001/XMLSchema#string

P932

4321242

http://www.w3.org/2001/XMLSchema#string