eIF2B, a mediator of general and gene-specific translational control.
about
eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranesPoor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter diseaseA yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseEctopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesisInhibition of glycogen synthase kinase 3[beta] activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnoverButanol production in S. cerevisiae via a synthetic ABE pathway is enhanced by specific metabolic engineering and butanol resistanceIdentification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complexeIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamicsPhosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.Control of translation initiation: a model-based analysis from limited experimental dataA quantitative estimation of the global translational activity in logarithmically growing yeast cellsDiscovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.Regulation of the unfolded protein response by eif2Bdelta isoforms.DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.Alcohols inhibit translation to regulate morphogenesis in C. albicansRapid turnover of mcl-1 couples translation to cell survival and apoptosis.GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?Less translational control, more memory.Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B.Global gene expression profiling of ischemic preconditioning in the rat retina.eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.CHOP and the endoplasmic reticulum stress response in myelinating gliaMapping the yeast host cell response to recombinant membrane protein production: relieving the biological bottlenecks.eIF5 is a dual function GAP and GDI for eukaryotic translational control.A new function and complexity for protein translation initiation factor eIF2BGlucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated.Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease.Using SILAC proteomics to investigate the effect of the mycotoxin, alternariol, in the human H295R steroidogenesis model.Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition.Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes.Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
P2860
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P2860
eIF2B, a mediator of general and gene-specific translational control.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
eIF2B, a mediator of general and gene-specific translational control.
@ast
eIF2B, a mediator of general and gene-specific translational control.
@en
eIF2B, a mediator of general and gene-specific translational control.
@nl
type
label
eIF2B, a mediator of general and gene-specific translational control.
@ast
eIF2B, a mediator of general and gene-specific translational control.
@en
eIF2B, a mediator of general and gene-specific translational control.
@nl
prefLabel
eIF2B, a mediator of general and gene-specific translational control.
@ast
eIF2B, a mediator of general and gene-specific translational control.
@en
eIF2B, a mediator of general and gene-specific translational control.
@nl
P356
P1476
eIF2B, a mediator of general and gene-specific translational control.
@en
P2093
P304
P356
10.1042/BST20051487
P577
2005-12-01T00:00:00Z