Two disparate ligand-binding sites in the human P2Y1 receptor.
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G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsStructural Studies of G Protein-Coupled ReceptorsLandmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structureExtra-helical binding site of a glucagon receptor antagonistMembrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR FunctionIn silico Approach for Anti-Thrombosis Drug Discovery: P2Y1R Structure-Based TCMs ScreeningHuman GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.Serial femtosecond crystallography opens new avenues for Structural Biology.The role of experimental and computational structural approaches in 7TM drug discovery.Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y 2 agonist, on cardiomyocytes in neonatal rats.Structural Analysis of Chemokine Receptor-Ligand Interactions.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Molecular Insights into the Transmembrane Domain of the Thyrotropin ReceptorMedicinal chemistry of adenosine, P2Y and P2X receptors.Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks.Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.New paradigms in GPCR drug discovery.The Molecular Mechanism of P2Y1 Receptor ActivationDiscovery of Potential Orthosteric and Allosteric Antagonists of P2Y1R from Chinese Herbs by Molecular Simulation Methods.Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities.Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine.Current strategies for protein production and purification enabling membrane protein structural biology.Allosteric binding: structures reveal new ways to tame G protein-coupled receptors.Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule BindingExpanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Structural studies of G protein-coupled receptors.ATP-induced Ca(2+)-signalling mechanisms in the regulation of mesenchymal stem cell migration.Micro-scale and rapid expression screening of highly expressed and/or stable membrane protein variants in Saccharomyces cerevisiae.Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6Structural insight into allosteric modulation of protease-activated receptor 2.Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y1 Receptor.Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor.Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracyHow Ligands Illuminate GPCR Molecular Pharmacology.7×7 RMSD matrix: A new method for quantitative comparison of the transmembrane domain structures in the G-protein coupled receptors.
P2860
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P2860
Two disparate ligand-binding sites in the human P2Y1 receptor.
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Two disparate ligand-binding sites in the human P2Y1 receptor.
@ast
Two disparate ligand-binding sites in the human P2Y1 receptor.
@en
Two disparate ligand-binding sites in the human P2Y1 receptor.
@nl
type
label
Two disparate ligand-binding sites in the human P2Y1 receptor.
@ast
Two disparate ligand-binding sites in the human P2Y1 receptor.
@en
Two disparate ligand-binding sites in the human P2Y1 receptor.
@nl
prefLabel
Two disparate ligand-binding sites in the human P2Y1 receptor.
@ast
Two disparate ligand-binding sites in the human P2Y1 receptor.
@en
Two disparate ligand-binding sites in the human P2Y1 receptor.
@nl
P2093
P2860
P50
P356
P1433
P1476
Two disparate ligand-binding sites in the human P2Y1 receptor.
@en
P2093
Cuiying Yi
Dandan Zhang
Evgeny Kiselev
Gye Won Han
Hualiang Jiang
Jiang Wang
Qiang Zhao
P2860
P2888
P304
P356
10.1038/NATURE14287
P407
P577
2015-03-30T00:00:00Z
P6179
1044590047