about
Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information.Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.Structure of the human P2Y12 receptor in complex with an antithrombotic drugAgonist-bound structure of the human P2Y12 receptorStructural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congenersSynthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine ReceptorDiscovery of novel A3 adenosine receptor ligands based on chromone scaffold.Two disparate ligand-binding sites in the human P2Y1 receptor.In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probesSynthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition processComputational studies to predict or explain G protein coupled receptor polypharmacologyJohn Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsRigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo EfficacyNovel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activityTruncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane SubstitutionsFluorescent ligands for adenosine receptors.Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Receptor-driven identification of novel human A₃ adenosine receptor antagonists as potential therapeutic agents.Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relation2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists.Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses.Species differences and mechanism of action of A3 adenosine receptor allosteric modulators.Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.A Novel Generalized 3D-QSAR Model of Camptothecin Analogs
P50
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P50
name
Silvia Paoletta
@en
type
label
Silvia Paoletta
@en
prefLabel
Silvia Paoletta
@en