WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
about
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasisWNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersIdentification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic IsolatesWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionWNK4 regulates apical and basolateral Cl- flux in extrarenal epitheliaSalt handling and hypertensionMultiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoformDomains of WNK1 kinase in the regulation of ROMK1Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type IIWNK kinases, renal ion transport and hypertensionRegulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.A molecular update on pseudohypoaldosteronism type IIIRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathwayWnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic interventionIn vivo Drosophilia genetic model for calcium oxalate nephrolithiasisLINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extensionMechanism and synergism in epithelial fluid and electrolyte secretion.Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransportWNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms.Comprehensive assessment of the association of WNK4 polymorphisms with hypertension: evidence from a meta-analysis.Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.WNK kinases and renal sodium transport in health and disease: an integrated view.The WNKs: atypical protein kinases with pleiotropic actions.Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.WNK4-mediated regulation of renal ion transport proteins.Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.Integrative network analysis reveals molecular mechanisms of blood pressure regulationRole of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.Bicarbonate promotes BK-α/β4-mediated K excretion in the renal distal nephronThe WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transportSlc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain.Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertensionThe kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Uriniferous tubule: structural and functional organization.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).
P2860
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P2860
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@ast
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@en
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@nl
type
label
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@ast
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@en
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@nl
prefLabel
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@ast
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@en
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@nl
P2093
P2860
P356
P1476
WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.
@en
P2093
Carol Nelson-Williams
Frederick H Wilson
Keith A Choate
Kristopher T Kahle
Richard P Lifton
P2860
P304
P356
10.1073/PNAS.242728499
P407
P577
2003-01-08T00:00:00Z