WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia. - Wikidata - wikimedia - TriplyDB

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.

http://www.wikidata.org/entity/Q34470465

about

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia Salt handling and hypertension Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform Domains of WNK1 kinase in the regulation of ROMK1 Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II WNK kinases, renal ion transport and hypertension Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.A molecular update on pseudohypoaldosteronism type II IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension Mechanism and synergism in epithelial fluid and electrolyte secretion.Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms.Comprehensive assessment of the association of WNK4 polymorphisms with hypertension: evidence from a meta-analysis.Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.WNK kinases and renal sodium transport in health and disease: an integrated view.The WNKs: atypical protein kinases with pleiotropic actions.Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.WNK4-mediated regulation of renal ion transport proteins.Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.Integrative network analysis reveals molecular mechanisms of blood pressure regulation Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.Bicarbonate promotes BK-α/β4-mediated K excretion in the renal distal nephron The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain.Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Uriniferous tubule: structural and functional organization.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).

P2860

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P2860

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.

http://www.wikidata.org/entity/Q34470465

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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Proceedings of the National Academy of Sciences of the United States of America

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WNK1, a kinase mutated in inhe ...... e Cl- -transporting epithelia.

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P2093

Carol Nelson-Williams

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Frederick H Wilson

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Keith A Choate

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Kristopher T Kahle

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Richard P Lifton

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P2860

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

Human hypertension caused by mutations in WNK kinases

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1.

Molecular mechanisms of human hypertension.

Fluid and electrolyte reabsorption in the ductuli efferentes testis.

Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization.

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

Electrolyte transport in the mammalian colon: mechanisms and implications for disease.

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663-668

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10.1073/PNAS.242728499

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2

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100

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2003-01-08T00:00:00Z

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5487412

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12522152

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141053

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