WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
about
Structural and functional diversity of the microbial kinomeWNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasisThe thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complexCharacterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamilyWNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathwayWNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersSLC26A9 is a Cl(-) channel regulated by the WNK kinasesWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateAntagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.Inflammatory bowel disease reveals the kinase activity of KSR1Molecular physiology of the thiazide-sensitive sodium-chloride cotransporterWNK4 regulates apical and basolateral Cl- flux in extrarenal epitheliaThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKsKSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoformDisease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudinsSerum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family membersDomains of WNK1 kinase in the regulation of ROMK1WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporterMutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type IIWNK kinases, renal ion transport and hypertensionWNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathwayRegulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinaseCharacterization of the kinase activity of a WNK4 protein complexIdentification of E-box factor TFE3 as a functional partner for the E2F3 transcription factorWNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cellsIntersectin links WNK kinases to endocytosis of ROMK1The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinationsMolecular mechanism of pancreatic and salivary gland fluid and HCO3 secretionA molecular update on pseudohypoaldosteronism type IIChloride Sensing by WNK1 Involves Inhibition of AutophosphorylationMEKK1 binds raf-1 and the ERK2 cascade componentsWNK kinases, a novel protein kinase subfamily in multi-cellular organismsHydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper dockingRegulation of WNK1 by an autoinhibitory domain and autophosphorylationWNK1 activates ERK5 by an MEKK2/3-dependent mechanismThe Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletionWNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertensionConservation, variability and the modeling of active protein kinasesAnalysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation
P2860
Q21563604-07CD25DD-EB52-4DD0-9101-405F0C49AFF8Q24294248-88945127-7786-4C90-890A-9DBB9A58A48FQ24299205-342DEEAB-D07D-46CF-B362-EA0C3E1725C1Q24304089-A67091CF-5722-4259-AA3C-2C6DA03CFBA8Q24310130-4F2F569C-FE0C-4BBE-87C8-27363F8DF3D9Q24311569-38F98C8C-7847-4599-A5ED-41151F6705CCQ24336113-477B6959-9272-45D5-B4B6-05AE222D634FQ24530650-DF1821D9-16A8-472D-BD0B-FDAF39638EC9Q24537454-FD2F6059-C9BE-43D3-A8DD-B9877746DB1FQ24562733-5E74882C-8553-47EE-95D6-16EC8F7BF91CQ24598213-7770F2A9-E88C-4004-9F0F-813565FE1799Q24621479-13BBAB5E-FA59-496E-A3DF-5A143076535BQ24623288-B439B1DA-4977-425F-BF99-034BECA14DC3Q24626430-BBBAB6C4-2E70-4E6E-8957-4ED9FB243DFFQ24633475-366B9598-19B5-4716-82CA-5B00A57939D4Q24633640-8C87089D-EC3E-4E28-B82B-7E46452FE7C1Q24633684-7CFF8289-2381-4C5B-B4ED-5F9FEACFA2A0Q24641916-FD940535-BAE3-475A-BC7E-ABF78E607427Q24646108-F60914D7-A8F9-4C30-AC7B-A8EF213ABDF7Q24648539-7C12B54A-76C3-4A53-B35C-9C85E159147BQ24649138-3B1466E5-808F-46A4-A9E2-05D9CC622DA6Q24652877-F497DBC7-E215-4BC6-A065-16CFF727B4CEQ24654826-CFD9ABEA-3ACE-494D-A38C-1F62CE1B84D6Q24658170-ED1616B3-C915-44E7-A1E7-C3C95AAAEB2AQ24673143-96A01585-1681-4AB6-960D-312F1BE6E6EAQ24676697-9B738A35-C90F-4A23-84B3-CDBD49A2F65AQ24680263-6B2AC710-A6B8-428A-BE03-94D3E1D2AF4CQ24803062-3F819212-84DA-4263-8857-7D427DD6D01BQ26852694-9C953179-32AC-4674-8803-CCA7C96D86F6Q27000474-72D981CC-3D76-40CE-B70F-A0328128C85FQ27683663-BB998A12-FEA1-487D-AFBD-6D314C4571A4Q28145204-2E85F168-A01F-4D10-BB75-2BC93218818CQ28188729-2C360F47-0653-45AA-8B07-9978A125F7B4Q28188989-BB0B3846-DCF9-492A-B7D6-8100016C7181Q28206619-E2075BE7-EDCD-4F80-AB9D-AFFAA3DE8E4CQ28234991-E1E4882E-DAC0-4F9E-9BAB-4D01ED6102FEQ28255750-26FD4F04-A3F2-4332-B0B5-FC5535BB5281Q28305389-010CCD1E-4148-499A-BD06-E9A01E74E286Q28469309-5BCB3EA2-28FE-45E6-B952-8F4414D39700Q28477794-B704C71D-9ADF-4516-8704-6928781D9174
P2860
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/02)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/02)
@nl
наукова стаття, опублікована в червні 2000
@uk
name
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@ast
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@en
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@nl
type
label
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@ast
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@en
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@nl
prefLabel
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@ast
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@en
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@nl
P2093
P2860
P356
P1476
WNK1, a novel mammalian serine ...... talytic lysine in subdomain II
@en
P2093
E J Goldsmith
J L Wilsbacher
J M English
P2860
P304
16795-16801
P356
10.1074/JBC.275.22.16795
P407
P577
2000-06-01T00:00:00Z