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Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

http://www.wikidata.org/entity/Q34471020

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The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration The critical role of membralin in postnatal motor neuron survival and disease Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality.Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease The unpredictability of prolonged activation of stress response pathways.Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells.Harnessing the integrated stress response for the treatment of multiple sclerosis.Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.Targeting IRE1 with small molecules counteracts progression of atherosclerosis.Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.Targeting the unfolded protein response for disease intervention.Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial).ER stress and the unfolded protein response in neurodegeneration.Protein misfolding in the endoplasmic reticulum as a conduit to human disease.TFG-Related Neurologic Disorders: New Insights Into Relationships Between Endoplasmic Reticulum and Neurodegeneration.Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action.Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia The unfolded protein response: mechanisms and therapy of neurodegeneration.The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.Recent advances in the genetic neuropathies.The integrated stress response.Modulation of VEGF receptor 2 signaling by protein phosphatases.Endoplasmic Reticulum Protein Quality Control Failure in Myelin Disorders.Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.Control of mRNA Translation in ALS Proteinopathy Integrated Stress Response as a Therapeutic Target for CNS Injuries.Fine-tuning PERK signaling for neuroprotection.The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance Miklós Bodanszky Award Lecture: Advances in the selective targeting of protein phosphatase-1 and phosphatase-2A with peptides.

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Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

http://www.wikidata.org/entity/Q34471020

description

2015 nî lūn-bûn

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2015 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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type

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Preventing proteostasis diseas ...... phosphatase regulatory subunit

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Agnieszka Krzyzosiak

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Kim Schneider

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Lawrence Wrabetz

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Maurizio D'Antonio

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Nicholas Barry

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P2860

An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans

Fiji: an open-source platform for biological-image analysis.

Adapting proteostasis for disease intervention

Perk is essential for translational regulation and cell survival during the unfolded protein response

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Regulated translation initiation controls stress-induced gene expression in mammalian cells

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Place navigation impaired in rats with hippocampal lesions

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6231

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Anne Bertolotti

Anna Gudný Sigurdardóttir

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2015-04-01T00:00:00Z

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