Selective elimination of mitochondrial mutations in the germline by genome editing - Wikidata - wikimedia - TriplyDB

Selective elimination of mitochondrial mutations in the germline by genome editing

Selective elimination of mitochondrial mutations in the germline by genome editing

http://www.wikidata.org/entity/Q34473537

about

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Strategies for precision modulation of gene expression by epigenome editing: an overview The application of CRISPR-Cas9 genome editing in Caenorhabditis elegans Mitochondrial transfer: Implications for assisted reproductive technologies Is there treatment for Leber hereditary optic neuropathy?Introduction of a male-harming mitochondrial haplotype via 'Trojan Females' achieves population suppression in fruit flies No evidence for strong cytonuclear conflict over sex allocation in a simultaneously hermaphroditic flatworm.Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Genome engineering: Drosophila melanogaster and beyond Modifying the Mitochondrial Genome.Emerging therapies for mitochondrial disorders.Mitochondria in pluripotent stem cells: stemness regulators and disease targets.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Mitochondrial donation and 'the right to know'.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Expert consensus document: Mitochondrial function as a therapeutic target in heart failure Mitochondrial Modification Techniques and Ethical Issues.Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis.Mutations causing mitochondrial disease: What is new and what challenges remain?Inherited mitochondrial genomic instability and chemical exposures.MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis.Novel reproductive technologies to prevent mitochondrial disease.Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Genome engineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells.Human mitochondrial nucleases.Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease.Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways.Aging Reversal and Healthy Longevity is in Reach: Dependence on Mitochondrial DNA Heteroplasmy as a Key Molecular Target.Gene mutation-based and specific therapies in precision medicine.Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease.Cholesterol Metabolism in T Cells.TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.Assisted reproductive technologies to prevent human mitochondrial disease transmission.Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.[Nuclear transfer to prevent transmission of mtDNA disorders: where are we?]Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

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P2860

Selective elimination of mitochondrial mutations in the germline by genome editing

http://www.wikidata.org/entity/Q34473537

description

2015 nî lūn-bûn

@nan

2015 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի ապրիլին հրատարակված գիտական հոդված

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

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name

Selective elimination of mitochondrial mutations in the germline by genome editing

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Selective elimination of mitochondrial mutations in the germline by genome editing

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Selective elimination of mitochondrial mutations in the germline by genome editing

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type

label

Selective elimination of mitochondrial mutations in the germline by genome editing

@ast

Selective elimination of mitochondrial mutations in the germline by genome editing

@en

Selective elimination of mitochondrial mutations in the germline by genome editing

@nl

prefLabel

Selective elimination of mitochondrial mutations in the germline by genome editing

@ast

Selective elimination of mitochondrial mutations in the germline by genome editing

@en

Selective elimination of mitochondrial mutations in the germline by genome editing

@nl

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J.CELL.2015.03.051

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P1476

Selective elimination of mitochondrial mutations in the germline by genome editing

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Alejandro Ocampo

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Atsushi Sugawara

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Carlos T Moraes

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Concepcion Rodriguez Esteban

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Daiji Okamura

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David Lam

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Dolors Manau

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Francesc Cardellach

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Guang-Hui Liu

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Huimin Zhao

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P2860

Ancient Invasions: From Endosymbionts to Organelles

A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia

Targeting DNA double-strand breaks with TAL effector nucleases

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

Mitochondrial DNA mutations in human disease

The maintenance of mitochondrial DNA integrity--critical analysis and update

Mitochondrial DNA disease-molecular insights and potential routes to a cure

Sequence and organization of the human mitochondrial genome

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

The role of mitochondrial DNA copy number in mammalian fertility.

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459-469

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scholarly article

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10.1016/J.CELL.2015.03.051

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Nuria Montserrat

Juan Carlos Izpisúa Belmonte

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2015-04-01T00:00:00Z

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25910206

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