Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis - Wikidata - wikimedia - TriplyDB

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

http://www.wikidata.org/entity/Q34480164

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Structure and function of biotin-dependent carboxylases Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit of Streptomyces coelicolor ,Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase Structure, Activity, and Inhibition of the Carboxyltransferase -Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis Antibacterial targets in fatty acid biosynthesis The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini Discovery of novel MDR-Mycobacterium tuberculosis inhibitor by new FRIGATE computational screen ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids Pleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteria Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes Structure-based substrate screening for an enzyme.Identifying co-targets to fight drug resistance based on a random walk model.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase The Corynebacterium pseudotuberculosis in silico predicted pan-exoproteome Comparative genomics provides evidence for the 3-hydroxypropionate autotrophic pathway in filamentous anoxygenic phototrophic bacteria and in hot spring microbial mats.Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Defining mycobacteria: Shared and specific genome features for different lifestyles Inhibiting bacterial fatty acid synthesis.Crystallization and preliminary crystallographic analysis of DtsR1, a carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum.A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium.Recent advances in antituberculous drug development and novel drug targets.Fatty acid biosynthesis in actinomycetes.The progress made in determining the Mycobacterium tuberculosis structural proteome Tuberculosis drugs: new candidates and how to find more.Structure, function and selective inhibition of bacterial acetyl-coa carboxylase.Navigating tuberculosis drug discovery with target-based screening.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Review of knowledge for rational design and identification of anti-tubercular compounds.Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.Enhancing microbial production of biofuels by expanding microbial metabolic pathways.

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P2860

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

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Proceedings of the National Academy of Sciences of the United States of America

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Structure-based inhibitor desi ...... of Mycobacterium tuberculosis

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Hugo Gramajo

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John Purdon

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Melrose M Melgar

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Pierre Baldi

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Shiou-Chuan Tsai

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Teresa Tseng

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Ting-Wan Lin

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P2860

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

The Envelope of Mycobacteria

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

The crotonase superfamily: divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

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9

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103

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S. Joshua Swamidass

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7284013

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16492739

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Mycobacterium tuberculosis

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1413898

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