The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. - Wikidata - wikimedia - TriplyDB

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

http://www.wikidata.org/entity/Q34484344

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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak Regulation of Bim in Health and Disease La FAM fatale: USP9X in development and disease Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling Comparison of Nanostring nCounter® Data on FFPE Colon Cancer Samples and Affymetrix Microarray Data on Matched Frozen Tissues.USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cells Molecular pathways: turning proteasomal protein degradation into a unique treatment approach.Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms.Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo.Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.USP9X destabilizes pVHL and promotes cell proliferation.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.MicroRNA-451 sensitizes lung cancer cells to cisplatin through regulation of Mcl-1.Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I).miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.Correlation of the expressions of IGF1R-RACK1-STAT3 and Bcl-xl in nasopharyngeal carcinoma with the clinicopathological features and prognosis of nasopharyngeal carcinoma.A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer.Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients.Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition

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The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

http://www.wikidata.org/entity/Q34484344

description

2012 nî lūn-bûn

@nan

2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

@ast

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

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The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

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type

label

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

@ast

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

@en

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

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prefLabel

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

@ast

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

@en

The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

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1471-2407-12-541

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The downregulation of Mcl-1 vi ...... d tumors to Bcl-xl inhibition.

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Arun Rai

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Chander Peddaboina

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Daniel Jupiter

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Jeremy L Yap

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M Karen Newell Rogers

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Philip Rascoe

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Richard P Tobin

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Steven Fletcher

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W Roy Smythe

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Weihua Jiang

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P2860

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Bcl-xL and Mcl-1 are involved in prevention of in vitro apoptosis in rat late-stage erythroblasts derived from bone marrow.

RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway.

Emerging Bcl-2 inhibitors for the treatment of cancer.

Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1.

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